放射性粒子组织间植入治疗胰腺癌疼痛疗效分析

Interstitial implantation of radioactive seeds for pancreatic cancer pain management

目的明确放射性粒子肿瘤内植入治疗胰腺癌疼痛的有效性和临床特点。方法回顾分析2008年1月至2019年7月在吉林大学中日联谊医院行放射性粒子植入治疗的160例胰腺癌临床资料,根据疼痛VAS法对术前、术后疼痛进行评估。结果160例患者中71.88%(115例)表现出腹部和(或)腰背部疼痛,放射性粒子植入术后104例疼痛不同程度缓解,止痛有效率90.43%,其中对腹痛的缓解率为86.52%,腰背部疼痛缓解率96.34%,两组间比较差异显著。疼痛开始缓解时间为术后1~7 d,从疼痛开始缓解到疼痛最大缓解程度所需时间为2 d~2周。结论放射性粒子肿瘤内植入治疗胰腺癌疼痛微创、迅速、有效。

Objective To assess the effectiveness and characteristics of intratumoral radioactive seed implantation in pancreatic cancer pain management.Methods Clinical data of 160 patients with pancreatic cancer receiving radioactive seed implantation were retrospectively analyzed.Both pre-and postoperative pain intensities were evaluated using the visual analog scale(VAS).Results About 71.88%(115)of 160 patients experienced abdominal or low back pain.Postoperative pain in 104 patients was relieved at various degrees after radioactive seed implantation with an analgesic efficacy of 90.43%(the efficacy for abdominal and low back pain relief was 86.52%and 96.34%,respectively).The between-group difference was statistically significant.Pain relief was observed 1-7 days postoperatively,and the maximal degree of pain relief was achieved 2-14 days after treatment initiation.Conclusion Intratumoral implantation of radioactive seeds was microinvasive,quick-acting,and effective in pancreatic cancer pain management.