血清sRANKL、Omentin-1水平与绝经后骨质疏松患者骨密度和骨代谢的关联

Association of serum sRANKL and Omentin-1 levels with bone mineral density and bone metabolism in postmenopausal osteoporosis patients

目的探讨血清可溶性细胞核因子κB受体活化因子配体(soluble receptor activator of nuclear factor-κB ligand,sRANKL)、网膜素-1(Omentin-1)水平与绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)的关联。方法选取2017年6月至2021年7月青岛市市立医院收治的310例绝经患者,其中PMOP患者165例,其余145例单纯绝经妇女作为对照组。采用ELISA检测患者血清sRANKL、Omentin-1水平;比较两组患者骨密度和骨代谢指标[Ⅰ型前胶原氨基末端前肽(N-terminal propeptide of typeⅠ precollagen,PINP)、骨碱性磷酸酶(bone alkaline phosphate,BALP)、β-Ⅰ型胶原C端肽(β isomer of the C-terminal telopeptide of type Ⅰ collagen,β-CTX)和骨钙素(osteocalcin,OC)]。采用Pearson分析PMOP组血清sRANKL、Omentin-1水平与骨密度、骨代谢指标的相关性。ROC曲线分析sRANKL、Omentin-1对PMOP的预测价值;Logistic回归分析多因素对PMOP的影响。结果与对照组(15.62±4.41)(42.56±8.53)比较,PMOP组血清sRANKL水平(26.63±8.12)升高,Omentin-1水平(32.32±5.52)降低(t=14.55,P<0.001;t=12.69,P<0.001)。经Pearson法分析,PMOP组血清sRANKL与PINP、β-CTX、OC呈正相关,血清Omentin-1水平与上述指标呈负相关。ROC曲线显示血清sRANKL、Omentin-1对预测PMOP有重要的参考意义。Logistic回归提示sRANKL升高和Omentin-1降低是PMOP的危险因素。结论 PMOP患者血清sRANKL、Omentin-1与骨密度、骨代谢指标有相关性,有作为PMOP诊断靶点的潜力。

Objective To investigate the relationship between serum soluble receptor activator of nuclear factor-κB ligand(sRANKL),Omentin-1 levels and postmenopausal osteoporosis(PMOP).Methods A total of 310 menopausal patients admitted to Qingdao Municipal Hospital from Jun.2017 to Jul.2021 were selected,including 165 patients with PMOP and 145 women with simple menopause as the control group.Serum sRANKL and Omentin-1 levels were detected by ELISA.Bone mineral density and bone metabolism indexes[N-terminal propeptide of typeⅠprecollagen(PINP),bone alkaline phosphatase(BALP),βisomer of the C-terminal telopeptide of typeⅠcollagen(β-CTX)and osteocalcin(OC)]were compared between the two groups.The correlation between serum sRANKL and Omentin-1 levels and bone mineral density and bone metabolism indexes in PMOP patients was analyzed by Pearson.The predictive value of sRANKL and Omentin-1 to PMOP was analyzed by ROC curve.Logistic regression analysis of the influence of multiple factors on PMOP.Results Compared with the control group(15.62±4.41)(42.56±8.53),the serum sRANKL level(26.63±8.12)was increased and Omentin-1 level(32.32±5.52)was decreased in PMOP group(t=14.55,P<0.001;t=12.69,P<0.001).The serum sRANKL in PMOP group was positively correlated with PINP,β-CTX and OC,while the serum Omentin-1 level was negatively correlated with the above indexes by Pearson analysis.ROC curve showed that serum sRANKL and Omentin-1 had important reference significance in predicting PMOP.Logistic regression suggested that increased sRANKL and decreased Omentin-1 were risk factors for PMOP.Conclusion Serum sRANKL and Omentin-1 in patients with PMOP are correlated with bone mineral density and bone metabolism,and have potential as diagnostic targets of PMOP.