PTEN在甲状腺恶性肿瘤中的研究进展

Progress of research on oncogene PTEN in thyroid malignant tumors

第10号染色体同源缺失性磷酸酶-张力蛋白(phosphatase and tensin homolog deleted on chromosome ten,PTEN)基因是位于人类10号染色体长臂上的10q23.3区域的一个常见的抑癌基因,其调节多种生物过程,如增殖、细胞结构、运动、能量代谢和基因组稳定性等。PTEN的失活在几乎所有的恶性肿瘤中普遍存在,并与肿瘤进展相关。甲状腺恶性肿瘤是最常见的内分泌恶性肿瘤之一,PTEN已被证实与其发生发展密切相关。本文旨在阐述PTEN的结构功能、总结和讨论PTEN在甲状腺恶性肿瘤中的最新发现。

The phosphatase and tensin homolog deleted on chromosome ten(PTEN)is a common oncogene located in the 10q23.3 region on the long arm of human chromosome l0,which regulates a variety of biological processes such as proliferation,survival,cell structure,motility,energy metabolism and genomic stability.Inactivation of PTEN is prevalent in almost all malignancies and correlates with tumor progression.Thyroid malignancies are among the most common endocrine malignancies,and PTEN has been shown to be critically associated with their development.The aim of this review is to describe the structural function of PTEN,as well as to summarize and discuss the recent findings of PTEN in thyroid malignancies.