细胞焦亡在胃癌治疗中的研究进展

Research progress of pyroptosis in the treatment of gastric cancer

细胞焦亡(pyroptosis)属于炎性细胞程序性死亡,受到GSDMD(Caspase-1、-4、-5-11)和GSDME(Caspase-3、颗粒酶)的调控,细胞焦亡的多条调控通路在胃癌细胞中异常表达,说明细胞焦亡与胃癌关系密切,有潜力成为胃癌治疗的新型靶点,与目前主流的治疗手段如化疗、免疫疗法等联合,有望提高胃癌的临床治疗效果。本文对细胞焦亡的分子机制,胃癌与细胞焦亡的相关研究,细胞焦亡与胃癌治疗的相关研究进行综述,探讨细胞焦亡作为胃癌新的靶标的可能性,为胃癌治疗提供新的研究思路。

Pyroptosis belongs to the programmed cell death of inflammatory cells,which is regulated by GSDMD(Caspase-1,-4,-5-11)and GSDME(Caspase-3,granzyme).Multiple regulatory pathways of pyroptosis are abnormally expressed in gastric cancer cells,indicating that pyroptosis is closely related to gastric cancer and has the potential to become a new target for gastric cancer treatment.Combined with current mainstream treatments such as chemotherapy and immunotherapy,it may improve clinical treatment effect of gastric cancer.This article reviews the molecular mechanism of pyroptosis,the related research on gastric cancer and pyroptosis,and the related research on pyroptosis and gastric cancer treatment to explore the possibility of pyroptosis as a new target for gastric cancer,and to provide new research ideas for gastric cancer treatment.