机械力环境影响头颈癌生物学行为及作用机制的研究进展

Advances in the effects of mechanical environment on the biological behaviors and mechanism of head and neck cancer

随着肿瘤细胞外基质力学特性逐步被认识,在二维和三维培养条件下考察机械力环境影响肿瘤生物学行为的研究也越来越多。机体的细胞外基质中存在各种机械力,这些力学信号可以转化为生化信号,改变组织细胞微环境并影响其代谢,从而驱动肿瘤发展。本文就拉伸力、压应力和流体剪切力这3种常见机械力对头颈癌细胞增殖、侵袭、迁移等生物学行为的影响及其相关机制进行文献回顾和综述,为进一步探讨机械力环境在头颈癌中发挥的作用提供依据。

With the gradual understanding of the mechanical properties of tumor extracellular matrix,research that focuses on tumor biological behavior by examining the mechanical environment in two-and three-dimensional culture conditions is also increasing.There are various mechanical stimulations in the extracellular matrix of the body.These mechanical signals can be converted into biochemical signals,changing the microenvironment of tissue cells and affecting their metabolism to drive the development of tumors.Therefore,in this paper,we review the effects of three common mechanical forces,including tension,compression,and fluid shear stress,on the biological behaviors of proliferation,migration,and invasion in head and neck cancer and related mechanisms.The aim is to gain a better understanding of the key role of mechanical environment in head and neck cancer.