微针在口腔医学中的应用

Application of microneedles in stomatology

微针(MN)是一种经皮给药装置,可突破口腔黏膜屏障递送药物经口腔颌面部静脉进入体循环而发挥药效。此外,将微针作用于口腔黏膜后可刺激机体立即启动创面愈合级联反应,激发多种生长因子释放,促进血管新生及胶原蛋白、弹性蛋白合成以实现组织再生。大量研究表明微针具备安全、无痛、微创、高效给药等应用特点。目前微针在药学领域和皮肤科领域已得到广泛应用,本文就微针在口腔医学中的应用进行综述。

Microneedles(MN)are transdermal drug delivery devices that can break through the oral mucosal barrier to deliver drugs into the body circulation through the oral and maxillofacial veins to exert drug effects.In addition,microneedles,when applied to the oral mucosa,can stimulate the body to immediately initiate a wound healing cascade response,stimulate the release of a variety of growth factors,promote vascular renewal and collagen and elastin synthesis to achieve tissue regeneration.Numerous studies have shown that microneedling is safe,painless,minimally invasive,and highly effective in drug delivery.At present,microneedling has been widely used in the fields of pharmacy and dermatology,and this paper reviews the application of microneedling in dentistry.