迷迭香酸药理作用及其递送系统的研究进展

Research progress on pharmacological effect and delivery system of rosmarinic acid

迷迭香酸是从迷迭香等植物中分离得到的一种多酚类化合物,具有显著的抗氧化、抗炎、抗微生物、抗肿瘤及神经保护等作用。然而,由于溶解度差、渗透性低、光不稳定性、体内靶向性差、代谢速率快等缺点,限制了其药理活性及临床产品开发。药物递送系统能够在改善药物的理化性质、保护药物稳定性、发挥更佳给药途径和提高生物利用度等方面具有显著优点。通过对迷迭香酸的药理作用及新型药物载体用于迷迭香酸递送的研究进展进行综述,为迷迭香酸的药物开发和临床应用提供参考。

Rosmarinic acid is a polyphenolic compound isolated from midiexiang(Rosmarinus officinalis)and other plants with significant anti-oxidant,anti-inflammatory,antibacterial,antitumor,and neuroprotective effects.However,rosmarinic acid has some disadvantages such as low solubility and permeability,photoinstability,in vivo poor targeting and fast metabolic rate,which limit its pharmacological activities and clinical drugs development.Drug delivery systems offer significant advantages in terms of improving the physicochemical properties,protecting stability,achieving better administration routes and increasing bioavailability.In this paper,the different pharmacological effects activities of rosmarinic acid were introduced,and the research progress of new carriers for the delivery of rosmarinic acid delivery systems were reviewed,which provide reference for the development and clinical application of rosmarinic acid.