基于非编码RNA的中药有效成分抗肿瘤作用机制研究进展

Research progress on antitumor mechanism of active components in traditional Chinese medicine based on non-coding RNA

非编码RNA(non-coding RNA,ncRNA)的失调与癌症的发生息息相关,并影响所有主要的癌症标志物。以ncRNA为切入点,根据中药药效物质基础及抗肿瘤机制,探究中药调控ncRNA诱导肿瘤细胞凋亡、抑制肿瘤细胞侵袭与迁移等作用机制,对于研发以ncRNA为基础的治疗药物具有重要意义。通过PubMed等数据库进行相关文献检索,对近5年有关中药调控ncRNA发挥抗肿瘤作用的研究进行综述,发现中药通过调节ncRNA,进而影响调节上皮间质转化、凋亡信号通路及耐药相关蛋白等多种途径,抑制肿瘤侵袭与迁移、促进肿瘤细胞凋亡和逆转肿瘤药物耐药的调控机制,为中药抗肿瘤药物相关研究提供参考。

The dysregulation of non-coding RNA is crucial associated with all types of cancer and affects nearly all major cancer markers.The non-coding RNA induces tumor cells apoptosis,inhibits tumor cell invasion and migration was discussed according to the pharmacodynamic material basis and anti-tumor mechanism of traditional Chinese medicine(TCM).It is of great significance for the development of non-coding RNA-based therapeutic drugs.The relevant literature was searched through PubMed and other databases,and the research on anti-tumor of non-coding RNA regulated by TCM in recent five years was reviewed.It was found that Chinese medicine affected epithelial-mesenchymal transition,apoptosis signaling pathway and drug-resistant proteins by regulating ncRNA.The regulation mechanism of inhibiting tumor invasion and migration,promoting tumor cell apoptosis and reversing tumor drug resistance,to provide certain reference and theoretical basis for the study on anti-tumor drugs of TCM.