残余胆固醇与非糖尿病人群颈动脉内膜–中膜厚度的相关性

Correlation between residual cholesterol and carotid intima-media thickness in non-diabetic population

目的探讨残余胆固醇(residual cholesterol,RC)与非糖尿病人群颈动脉内膜–中膜厚度(carotid intima-media thickness,cIMT)的相关性。方法回顾性纳入2018年1月1日至2021年12月31日期间在南京大学医学院附属鼓楼医院接受健康检查的非糖尿病人群。根据颈动脉超声结果分为cIMT增厚组(≥1 mm)和非增厚组(<1 mm)。根据总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)和高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)计算RC水平。应用多变量logistic回归分析确定RC与cIMT的相关性。结果共纳入1 803例非糖尿病受试者,年龄(58.3±15.6)岁,男性1 100例(61.0%);cIMT增厚组916例(50.8%),非cIMT增厚组887例(49.2%)。与非cIMT增厚组相比,cIMT增厚组男性、高血压、高脂血症、心房颤动、既往卒中史、吸烟和饮酒的构成比以及年龄、血糖、甘油三酯、RC、TC、LDL-C显著更高,而HDL-C则显著更低(P均<0.01)。多变量logistic回归分析显示,RC与cIMT增厚独立相关(P趋势<0.001)。结论 RC与非糖尿病人群cIMT增厚相关。

Objective To investigate the correlation between residual cholesterol(RC)and carotid intima-media thickness(cIMT)in non-diabetic population.Methods Non-diabetes population received health examination in Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School from January 1,2018 to December 31,2021 were retrospectively included.According to the carotid ultrasound results,they were divided into cIMT thickening group(≥1 mm)and non-thickening group(<1 mm).The RC level was calculated according to total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C).Multivariate logistic regression analysis was used to determine the correlation between RC and cIMT.Results A total of 1803 non-diabetes subjects,aged 58.3±15.6 years,including 1100 males(61.0%),were enrolled.There were 916 patients(50.8%)in the cIMT thickening group and 887(49.2%)in the non-cIMT thickening group.Compared with the non-cIMT thickening group,cIMT thickening group had significantly higher proportion of male,hypertension,hyperlipidemia,atrial fibrillation,past stroke history,smoking and alcohol consumption,as well as significantly higher age,blood glucose,triglyceride,RC,TC and LDL-C,and significantly lower HDL-C(all P<0.01).Multivariate logistic regression analysis showed that RC was independently associated with cIMT thickening(Ptrend<0.001).Conclusion RC is associated with cIMT thickening in non-diabetes population.