戒烟联合氟替美维对稳定期慢性阻塞性肺疾病合并呼吸衰竭患者的改善效果

Quitting smoking combined with flutamide on the improvement in patients with stable COPD complicated with respiratory failure

目的对稳定期慢性阻塞性肺疾病(COPD)合并呼吸衰竭患者采用戒烟联合氟替美维,分析对其肺功能、运动功能的改善效果。方法通过便利抽样、对照原则回顾性研究2020年1月至2022年1月聊城市第二人民医院接诊的100例稳定期COPD合并呼吸衰竭患者,给予氟替美维治疗的为对照组(n=50),给予戒烟联合氟替美维治疗的为观察组(n=50),比较两组临床疗效、肺功能指标、6分钟步行试验(6WMT)、呼吸困难评分(mMRC)、血清炎症指标。结果观察组临床总有效率(94.00%)高于对照组(72.00%)(P<0.01),治疗后,观察组用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、FEV_(1)/FVC均高于对照组(P<0.05),6WMT高于对照组(P<0.05),mMRC评分低于对照组(P<0.05),血清肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-8、IL-6均低于对照组(P<0.05)。结论戒烟联合氟替美维可有效改善稳定期COPD合并呼吸衰竭患者肺功能、运动功能,减轻呼吸困难程度与机体炎症反应。

Objective To explore the effect of smoking cessation combined with flutamide on improving the lung function and motor function in stable chronic obstructive pulmonary disease(COPD)patients complicated with respiratory failure.Methods A retrospective study was conducted on 100 stable COPD patients complicated with respiratory failure treated from January 2020 to January 2022 at the Second People's Hospital of Liaocheng through convenience sampling and control principles.The patients who were treated with flutimevir served as the control group(n=50),and those who were given smoking cessation combined with flutimevir served as the observation group(n=50).The clinical efficacy,pulmonary function indexes,6-minute walk test(6WMT),dyspnea score[modified Medical Research Council(mMRC)]and serum inflammation markers were compared between two groups.Results The total effective rate in observation group was significantly higher than that in control group(94.00%vs 72.00%,P<0.01).After treatment,forced vital capacity(FVC),forced expiratory volume in the first second(FEV_(1))and FEV_(1)/FVC ratio in observation group were statistically higher than those in control group(P<0.05).Compared with those in control group,6WMT increased,and mMRC score and levels of serum tumor necrosis factor-α(TNF-α),interleukin(IL)-8 and IL-6 decreased significantly in observation group(P<0.05).Conclusion For the stable COPD patients complicated with respiratory failure,smoking cessation combined with flutamide can effectively improve the pulmonary function and motor function and significantly reduce the degree of dyspnea and the inflammatory response.