SFTPB在甲状腺乳头状癌中的表达及其临床意义

Expression of SFTPB in papillary thyroid carcinoma and its clinical significance

目的探讨甲状腺乳头状癌(PTC)组织SFTPB表达水平变化及其与中央区淋巴结转移的关系。方法回顾性分析2018年6月至2022年6月南京大学医学院附属金陵医院甲状腺乳腺外科收治的甲状腺乳头状癌患者104例临床资料。所有患者均行甲状腺全切除术及中央区淋巴结清扫手术,取术中癌组织及配对的癌旁组织样本,经免疫组化SP法评价样本中目的蛋白表达量。比较癌组织与癌旁正常组织SFTPB的表达差异,并分析SFTPB表达量以及相关临床病理参数与中央区淋巴结转移的相关性。结果SFTPB在PTC癌组织中的表达量明显高于癌旁组织(P<0.001),在合并中央区淋巴结转移组中的表达量明显高于中央区淋巴结未转移组(P<0.001)。Logistic回归分析显示,性别、年龄及SFTPB表达量是预测PTC患者中央区淋巴结转移的独立影响因素。结论甲状腺乳头状癌组织中SFTPB表达量升高,且表达量越高者发生中央区淋巴结转移的可能性越大。

Objective To investigate the change of SFTPB expression level in papillary thyroid carcinoma(PTC)tissue and its relationship with lymph node metastasis in the central region of neck.Methods From June 2018 to June 2022,104 patients with PTC admitted to the Department of Thyroid and Breast Surgery of Jinling Hospital Affiliated to the Medical School of Nanjing Universi⁃ty,were selected to perform total thyroidectomy and central lymph nodes dissection,and the samples of cancer tissue and paired para⁃cancerous tissue were taken to evaluate the SFTPB protein expression in the specimens by IHC.The expression of SFTPB in cancer tis⁃sues and para⁃cancerous tissue was compared,and the correlation of SFTPB expression and related clinicopathological parameters with central lymph node metastasis was analyzed.Results The expression of SFTPB in cancer tissue was significantly higher than that in para⁃cancerous tissue(P<0.001),and the expression level in the group with central lymph node metastasis was significantly higher than that in the group without central lymph node metastasis(P<0.001).Logistic regression analysis showed that gender,age and SFT⁃PB expression were independent factors in predicting central lymph node metastasis in PTC patients.Conclusion The expression level of SFTPB in PTC was increased,and the higher the expression level was,the more likely the central lymph node metastasis was.