非侵入性脑刺激在抑郁症精准医疗中的研究进展

Research progress on non-invasive brain stimulation in precision medicine for depression

抑郁症严重影响患者的日常工作生活,并导致巨大的经济和医疗负担。非侵入性脑刺激(NIBS)作为一种无创的神经调控手段在抑郁症的非药物治疗中应用越来越广泛。精准医疗模式是现阶段精神科诊疗领域的新趋势。经过近二十年的飞速发展,目前NIBS治疗精神疾病的技术已经拥有了较为丰富的神经影像学研究基础,这使其可以在一个精准医学的框架内从多个维度上开发个性化的干预措施,例如寻找更加精确的治疗参数算法,关注大脑状态目标扩展频率参数空间和寻找患者的生物亚型证据等以达到提升患者疗效的目的。现对目前NIBS在抑郁症治疗领域向精准医疗方向的努力和进展进行综述。

Depression seriously affects the daily work and life of patients,and leads to a huge financial and medical burden.Non-invasive brain stimulation(NIBS),as a non-invasive neuromodulation method,has been widely used in the non-drug treatment of depression.Precision medicine is a new trend in biomedical oriented depression diagnosis and treatment.After nearly two decades of rapid development,NIBS is now based on rich data from neuroimaging studies,which allows it to develop personalized interventions from multiple dimensions within a precision medicine framework,such as finding more precise treatment parameter algorithms,focus on brain state goals to expand frequency parameter space and search for evidence of patients'biological subtypes to achieve the purpose of improving patient efficacy.This paper reviews the current NIBS efforts and progress towards precision medicine in the field of depression treatment.