3D生物打印技术在真皮再生中的研究进展

Research progress of 3D bioprinting technology in dermal regeneration

皮肤软组织缺损在临床十分常见。真皮组织的损伤修复很大程度决定了皮肤软组织缺损的修复效果及瘢痕形成情况。3D生物打印是一种新兴的技术,可以实现生物材料和活性细胞等成分的精确分布,从而构建复杂、立体的结构,为真皮组织的再生修复提供支持。由于打印技术、生物墨水及种子细胞等方面的限制,目前3D生物打印技术应用于皮肤再生仍处于实验室阶段。随着3D生物打印工艺的不断发展,特别是生物墨水的开发及打印技术的优化,高分辨3D打印将能定制出更为精细的功能化皮肤模型,甚至包含皮肤附属器官,为真皮的再生修复提供新的治疗策略。

Soft tissue defects of skin are common in clinical practice.The restoration of dermal damage,to a large extent,contributes to the repairing effects and scar formation of skin soft tissue defects.Three-dimensional(3D)bioprinting is an emerging technology that can accurately distribute biomaterials and living cells.It creates intricate stereoscopic structures which facilitates regenerative repair of dermal defects.Due to limitations of printing method,bio-ink,and seed cells,3D bioprinting technology for skin is still in the lab stage.With the development of 3D bioprinting,especially in novel bio-ink exploitation and technical optimization,high resolution 3D bioprinting will enable us to customize elaborate functionalized skin models and even cutaneous appendages,providing new strategies in dermal regenerative repairment.