组织工程化韧带及其材料的研究进展

Research progress of tissue engineering ligament and scaffold materials

现有人工韧带产品的重建方案在临床应用中已相对成熟,为防止韧带重建术后的腱-骨愈合困难、骨隧道扩大、滑膜炎性反应、感染、外固定松动等术后并发症的出现,利用组织工程技术构建肌腱组织成为今后可能的发展方向。本文综述组织工程化肌腱的构建及其支架材料的进展,探讨其中亟待解决的问题与未来的发展方向。

The reconstruction scheme of the existing artificial ligament products has been relatively mature in clinical application.In order to prevent the occurrence of postoperative complications such as difficult tendon-bone healing,expansion of the bone tunnel,synovial inflammatory reaction,infection,and external fixation loosening after ligament reconstruction,tendon tissue construction using tissue engineering technology has become a possible development direction in the future.In this paper,the progress of the construction of tissue-engineered tendon and its scaffold materials was reviewed,the urgent problems to be solved and the future development direction were discussed.