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系统性红斑狼疮患者甲基-CpG结合蛋白2基因表达水平及其与DNA甲基化相关性的初步研究 被引量:1

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摘要 系统性红斑狼疮(SLE)是一种病因未明的累及全身多器官的慢性进行性病谱性自身免疫病。表观遗传学研究显示,DNA低甲基化为解释SLE发病机制和开发新的治疗策略提供了新的线索。DNA低甲基化通过促进CD11a/CD18、CD70等共刺激分子的表达,使得T细胞具有自身反应性。
出处 《临床皮肤科杂志》 CAS CSCD 北大核心 2023年第7期402-404,共3页 Journal of Clinical Dermatology
基金 国家自然科学基金(81371745)资助项目。
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