肠道菌群与早发性卵巢功能不全相关性研究进展

Research progress on the correlation between intestinal flora and premature ovarian insufficiency

早发性卵巢功能不全(Premature Ovarian Insufficiency,POI)指女性在40岁以前出现的卵巢功能减退,主要表现为月经异常、雌激素波动性下降等症状。此病发病率逐年升高,并严重影响女性的身心健康。POI有多种病因,包括遗传、自身免疫、医源性和环境污染物等,但多数患者的发病原因目前仍未阐明。近年来,肠道菌群与妇科代谢类疾病之间的关联研究逐渐成为热门话题。近期研究发现卵巢功能衰退与肠道菌群紊乱相关,随着研究的深入,还发现肠道菌群与POI并发症也有密切关系。文章初步探讨肠道微生物与POI伴随症状之间的相关性,为临床治疗POI提供新的思路。

Premature ovarian insufficiency(POI)refers to the decline of ovarian function in women before the age of 40,mainly manifested by abnormal menstruation,decreased estrogen volatility and other symptoms.The incidence rate of POI is increasing year by year,and seriously affects women's physical and mental health.There are many causes of POI,including heredity,autoimmunity,iatrogenic and environmental pollutants,but the causes of most patients have not been clarified.In recent years,the relationship between intestinal flora and gynecological metabolic diseases has gradually become a hot topic.Recent studies have found that the decline of ovarian function is related to the disorder of intestinal flora.Therefore,this paper preliminarily discusses the correlation between intestinal microorganisms and the accompanying symptoms of POI,so as to provide new ideas for the clinical treatment of POI.