支气管肺泡灌洗液中APOA1、CO4A、CRP的表达水平联合检测对非小细胞肺癌的诊断价值

The Combined Diagnostic Value of APOA1,CO4A,CRP Expression Levels in Bronchoalveolar Lavage Fluid for Non-small Cell Lung Cancer

目的探讨支气管肺泡灌洗液中载脂蛋白A1(Apolipoprotein A1,APOA1)、补体成分4A(Complement Component 4A,CO4A)、C反应蛋白(C-Reactive Protein,CRP)的表达水平联合检测对非小细胞肺癌的诊断价值。方法纳入非小细胞肺癌患者92例为癌症组,肺炎患者30例为肺炎组,支气管炎患者30例为支气管炎组,肺结节患者30例为肺结节组,健康志愿者92例为对照组。检测5组人员支气管肺泡灌洗液中APOA1、CO4A、CRP的表达水平。用受试者工作特征曲线(receiver operating characteristic curve,ROC)的AUC分析支气管肺泡灌洗液中APOA1、CO4A、CRP检测在非小细胞肺癌中的诊断意义。结果癌症组受试人员支气管肺泡灌洗液中APOA1、CO4A、CRP以及血清中CA125的表达水平均高于肺炎组、支气管炎组、肺结节组和对照组受试人员(P<0.05)。支气管肺泡灌洗液中APOA1、CO4A、CRP以及血清中CA125单独诊断癌症组和非癌症组的灵敏度分别为91.05%、90.35%、92.45%、83.04%,特异度分别为91.14%、91.22%、93.06%、85.24%。支气管肺泡灌洗液中APOA1、CO4A、CRP联合对非小细胞肺癌的诊断的灵敏度为98.91%,特异度为90.22%,准确性为93.12%。支气管肺泡灌洗液中APOA1、CO4A、CRP的表达水平与非小细胞肺癌大小正相关。结论支气管肺泡灌洗液中APOA1、CO4A、CRP的表达水平检测可作为非小细胞肺癌的潜在诊断指标。

Objective To investigate the diagnostic value of expression levels of Apolipoprotein A1(Apolipoprotein A1,APOA1),Complement Component 4A(CO4A)and C-Reactive Protein(CRP)in bronchoalveolar lavage fluid for non-small cell lung cancer.Methods A total of 92 patients with non-small cell lung cancer were the cancer group,30 patients with pneumonia were in the pneumonia group,and 30 patients with bronchitis were in the bronchitis group,30 patients with pulmonary nodules were in the pulmonary nodule group,and 92 healthy volunteers were the control group.The expression levels of APOA1,CO4A,CRP in the bronchoalveolar lavage fluid of the 5 groups were detected.The AUC of receiver operating characteristic curve(receiver operating characteristic curve,ROC)was used to analyze the diagnostic significance of APOA1,CO4A,and CRP in bronchoalveolar lavage fluid in non-small cell lung cancer.Results The expression levels of APOA1,CO4A,CRP and CA125 in the bronchoalveolar lavage fluid of the cancer group were higher than those of the pneumonia group,bronchitis group,pulmonary nodule group and the control group(P<0.05).The sensitivity of APOA1,CO4A,CRP in bronchoalveolar lavage fluid and CA125 in serum for one-way diagnosis of cancer group and non-cancer group were 91.05%,90.35%,92.45%,83.04%,and specificity were 91.14%,91.22%,93.06%,85.24%.The sensitivity of the combination of APOA1,CO4A,and CRP in bronchoalveolar lavage fluid for the diagnosis of non-small cell lung cancer is 98.91%,the specificity was 90.22%,and the accuracy was 93.12%.The expression levels of APOA1,CO4A and CRP in bronchoalveolar lavage fluid are positively correlated with the size of non-small cell lung cancer.Conclusion The detection of APOA1,CO4A and CRP expression levels in bronchoalveolar lavage fluid can be used as potential markers of non-small cell lung cancer.