Rap1b蛋白在子宫内膜癌组织中的表达及其临床意义

Expression of Rap1b Protein in Endometrial Carcinoma and its Clinical Significance

目的探讨Rap1b蛋白在子宫内膜癌组织中的表达及与其临床病理参数的关系。方法选取子宫内膜癌组织标本82例(癌组织)。同时期选取子宫脱垂等手术过程中获取的正常子宫内膜组织标本45例(正常组织)。观察2组Rap1b蛋白阳性率、Rap1b蛋白表达与子宫内膜癌临床病理参数的关系、患者预后与Rap1b蛋白表达相关性。结果癌组织中Rap1b蛋白阳性率(70.73%)显著高于正常组织,差异具有统计学意义(P<0.05)。不同病理分级、不同FIGO分期、有无淋巴结转移的子宫内膜癌患者Rap1b蛋白表达阳性率比较,差异均具有统计学意义(P<0.05)。经过3年随访后,82例子宫内膜癌患者中死亡8例,存活率为90.24%(74/82),其中8例死亡患者中Rap1b蛋白阳性有6例。23例复发,复发率为20.73%(17/82)。Rap1b阳性组3年累积存活率[87.93%(51/58)]低于Rap1b阴性组[95.83%(23/24)](χ^(2)=1.204,P=0.273)。结论Rap1b蛋白在子宫内膜癌组织内呈现高表达,主要与病理分级、FIGO分期、淋巴结转移存在关系,且与患者预后存在正相关,其可作为子宫内膜癌患者病情评估检测指标。

Objective To investigate the expression of Rap1b protein in endometrial carcinoma and its relationship with clinicopathologic parameters.Methods 82 cases of endometrial carcinoma were selected.At the same time,45 cases of normal endometrial tissue samples obtained during uterine prolapse and other operations were selected(normal tissue).The positive rate of Rap1b protein,the relationship between Rap1b protein expression and clinicopathologic parameters of endometrial cancer,and the correlation between prognosis and Rap1b protein expression were observed in the 2 groups.Results The positive rate of Rap1b protein in cancer tissue(70.73%)was significantly higher than that in normal tissue,with statistical significance(P<0.05).The positive rate of Rap1b protein expression in endometrial cancer patients with different pathological grades,different FIGO stages and with or without lymph node metastasis was statistically significant(P<0.05).After 3 years of follow-up,8 of 82 patients with endometrial cancer had died,with a survival rate of 90.24%(74/82).Rap1b protein positive was found in 6 of 8 patients.23 patients relapsed,and the recurrence rate was 20.73%(17/82).The 3-year cumulative survival rate in Rap1b positive group[87.93%(51/58)]was lower than that in Rap1b negative group[95.83%(23/24)](χ^(2)=1.204,P=0.273).Conclusion Rap1b protein is highly expressed in endometrial cancer tissues,which is mainly related to pathological grade,FIGO stage and lymph node metastasis,and is positively correlated with the prognosis of patients.Rap1b protein can be used as an indicator to evaluate the disease status of patients with endometrial cancer.