中药多糖治疗抑郁症的作用机制的研究进展

Research progress on the mechanism of traditional Chinese medicine polysaccharide in treating depression

中药多糖具有抗感染、抗氧化、免疫调节等多种活性,其优势在于毒副作用小、安全性高、功能多样。多糖通过炎症反应通路、神经递质通路、HPA轴、信号转导通路等途径可抑制抑郁症的发病进程。本文还总结分析了中药多糖目前存在问题和下一步研究重点,以期为抑郁症治疗靶点与机制、中药多糖有效成分研究与开发提供科学依据和新思路。

Traditional Chinese medicine polysaccharide has anti-inflammatory,antioxidant and immunomodulatory activities,and its advantages lie in low toxicity and side effects,high safety,and diverse functions.Polysaccharide can inhibit the progression of depression through inflammatory response pathway,neurotransmitter pathway,HPA axis,signal transduction pathway,and other pathways.This paper also summarizes and analyzes the existing problems of traditional Chinese medicine polysaccharide and the next research focus,in order to provide scientific basis and new ideas for the research and development of the target and mechanism of depression treatment and the effective components of traditional Chinese medicine polysaccharide.