基于数据挖掘探讨《伤科补要》治伤用药规律研究

Study on the rules of injury-treating medication in Buyao of the Wounded Department based on data mining

目的探讨《伤科补要》治疗骨伤用药规律。方法整理中治伤的内服及外用方剂,参考《中华人民共和国药典》及中药学对药物性味归经、功效进行归纳,使用SPSS Modeler 14.1进行复杂网络图展示并关联规则分析。统计药物使用频率,对高频中药进行聚类分析。结果共涉及95个内服方,35个外用方。内服药物中使用频率≥10次的中药共24味;外用药物≥5次的共16味;内服和外用药物多见性温,以辛、苦和甘味为主;归经多见心、肝;功效以活血化瘀和补虚为主。关联规则得出川芎-当归等13组内服核心药物,乳香-没药等5组外用核心药物;聚类分析内服药物共4类,外用药物共3类。结论该书以活血化瘀、补益气血、敛疮生肌为主要思想,运用当归、川芎等内服药物和乳香、没药等外用药物治疗骨伤科疾病,为临床治疗骨伤科疾病提供了一定的借鉴。

Objective To explore the drug law of treating bone injury in“Buyao of the Wounded Department”.Methods The internal and external prescriptions for the treatment of injuries were sorted out,and the meridian normalization and efficacy of the drugs were summarized by referring to the Pharmacopoeia of the People’s Republic of China and traditional Chinese medicine.SPSS Modeler 14.1 was used for complex network diagram display and association rule analysis.Results A total of 95 prescriptions for internal administration and 35 for external use were involved.There were 24 traditional Chinese medicine with a frequency of≥10 times for internal administration;16 tastes of external drugs≥five times;for internal and external use,most drugs were warm,mainly sweet,bitter,and sweet.Return to the meridian to see more heart,liver;the main effect was to promote blood stasis and tonify deficiency.Association rules showed that 13 groups of internal core drugs such as Rhizoma Ligustici Chuanxiong-Radix Angelicae Sinensis,and five groups of external core drugs such as Olibanum and Myrrha.Cluster analysis included four types of drugs for internal use and three types of drugs for external use.Conclusion The book takes promoting blood circulation and removing blood stasis,tonifying qi and blood,collecting soreness and generating muscle as the main ideas,and uses internal medicines such as Radix Angelicae Sinensis,Rhizoma Ligustici Chuanxiong as well as external medicines such as Olibanum and Myrrha to treat orthopedic diseases,providing certain references for clinical treatment of orthopedic diseases.