摘要
结核病是由结核分枝杆菌(MTB)感染引起的全球性公共疾病。结核病的治疗需要长期使用多种药物,并因依从性和耐药性问题变得复杂且漫长。MTB对药物的敏感性一定程度上是由细菌和宿主巨噬细胞相互作用决定的。MTB感染人体后主要存在于巨噬细胞内,通过抑制巨噬细胞生理活性使机体处于被感染状态。离子通道阻滞剂影响离子通道活性调节巨噬细胞内信号离子浓度,增强宿主巨噬细胞对MTB的杀伤作用,同时抑制MTB外排泵活性,提高MTB对药物的敏感性。本文综述了部分对MTB有效的离子通道阻滞剂,初步探索了其抗结核的作用机制,希望能为抗结核新药的研发提供新的思路。
Tuberculosis is a global public health disease caused by Mycobacterium tuberculosis(MTB)infection.The treatment of tuberculosis requires long-term use of multiple drugs,and becomes complicated and lengthy due to compliance and drug resistance.The sensitivity of MTB to drugs is to some extent determined by the interaction between bacteria and host macrophages.MTB mainly exists in macrophages after infecting the human body,and by inhibiting the physiological activity of macrophages,the body is in an infected state.Ion channel blockers regulate the concentration of signaling ions in macrophages by affecting the activity of ion channels,enhance the killing effect of host macrophages on MTB,and inhibit the activity of MTB efflux pumps,and improve the sensitivity of MTB to drugs.This article reviews some effective ion channel blockers for MTB and preliminarily explores their anti-tuberculosis mechanisms,hoping to provide new ideas for the development of new anti-tuberculosis drugs.
作者
罗水清
曾娅莉
LUO Shuiqing;ZENG Yali(School of Clinical Medicine,Southwest Medical University,Sichuan Province,Luzhou 646000,China;Department of Medical Laboratory,Sichuan Mianyang 404 Hospital,Sichuan Province,Mianyang 621000,China)
出处
《中国医药导报》
CAS
2023年第17期57-60,共4页
China Medical Herald
基金
四川省重点研发项目(2019YFS0090)。
