HE4联合CA125、VEGF对子宫内膜癌早期诊断及预后的评估价值

Evaluation Value of HE4 Combined with CA125 and VEGF in Early Diagnosis and Prognosis of Endometrial Cancer

目的探讨HE4联合CA125、VEGF对子宫内膜癌早期诊断及预后的评估价值。方法选择2019年1月—2020年12月湛江中心人民医院收治的子宫内膜癌(为子宫内膜恶性病变组)和子宫内膜良性病变患者(为子宫内膜良性病变组)各40例为研究对象。比较不同子宫内膜病变患者HE4、CA125和VEGF水平,统计HE4、CA125和VEGF单纯及联合诊断子宫内膜癌的效能。结果子宫内膜恶性病变组HE4、CA125和VEGF水平分别为(76.8±15.4)pmol/L,(33.6±5.5)U/mL和(68.9±16.1)mg/L均显著高于子宫内膜良性病变组,差异有统计学意义(P<0.05)。HE4、CA125和VEGF 3者联合检测其诊断敏感度、特异度均大于HE4、CA125和VEGF单独检测,HE4、CA125和VEGF单独检测曲线下面积(AUC)分别为0.695、0.632和0.389,3者联合检测的AUC为0.782。结论HE4、CA125和VEGF3者联合诊断子宫内膜癌,具有较高的诊断敏感度与特异度。

Objective To investigate the evaluation value of HE4 combined with CA125 and VEGF in the early diag-nosis and prognosis of endometrial cancer.Methods A total of 40 patients with endometrial cancer(endometrial malig-nant lesion group)and 40 patients with endometrial benign lesion group(endometrial benign lesion group)admitted to Zhanjiang Central People´s Hospital from January 2019 to December 2020 were selected as subjects.The levels of HE4,CA125 and VEGF in patients with different endometrial lesions were compared,and the diagnostic efficacy of HE4,CA125 and VEGF alone or combined was evaluated.Results The levels of HE4,CA125 and VEGF in endometrial malignant lesion group were(76.8±15.4)pmol/L,(33.6±5.5)U/mL and(68.9±16.1)mg/L,respectively,which were significantly higher than those in endometrial benign lesion group,and the difference was statistically significant(P<0.05).The combined diagnostic sensitivity,specificity of HE4,CA125 and VEGF3 were greater than those of HE4,CA125 and VEGF alone,and the area under the curve(AUC)of HE4,CA125 and VEGF alone were 0.695,0.632 and 0.389,respectively.The AUC of the three combined tests was 0.782.Conclusion The combination of HE4,CA125 and VEGF3 in the diagnosis of endometrial cancer has high diagnostic sensitivity and specificity.