轻度认知功能障碍与肝胆系统异常相关性研究进展

Research Progress on the Correlation between Mild Cognitive Impairment and Hepatobiliary System Abnormalities

轻度认知功能障碍(mild cognitive impairment,MCI)因其高发病率、强隐匿性、低治疗率且没有公认的治疗药物而在神经病学领域被广泛关注。关于MCI的高危因素除了环境、生活方式、遗传方面的因素外,各个全身的系统性疾病可能都与认知功能受损有关,本文围绕胆固醇、胆红素、胆道系统疾病、肝脏疾病及中医论“肝”等肝胆系统疾病与MCI发生、发展的流行病学、病理学及治疗学等方面进行文献综述,探索肝胆系统疾病与MCI发生、发展的机理,为进一步防治MCI提供理论依据。

Mild cognitive impairment(MCI)has been widely concerned in the field of neurology because of its high incidence,strong concealment,low treatment rate and no recognized therapeutic drugs.In addition to environmental,lifestyle,and genetic factors,various systemic diseases of the whole body may be related to impaired cognitive function.This article reviews the literature on the epidemiology,pathology and therapeutics of hepatobiliary system diseases and the occurrence and development of MCI,including cholesterol,bilirubin,biliary system diseases,liver diseases,and"liver"in traditional Chinese medicine,explores the mechanism of hepatobiliary system diseases and the occurrence and development of MCI,and provides a theoretical basis for further prevention and treatment of MCI.