QEEG中慢波与颞叶癫痫患者认知功能障碍相关性分析

Correlation of slow wave on quantitative electroencephalography with cognitive dysfunction in patients with temporal lobe epilepsy

目的探究定量脑电图中慢波和认知功能障碍的相关性。方法收集2022年1月-2022年10月在赤峰学院附属医院就诊的颞叶癫痫患者80例,对入组患者进行蒙特利尔MoCa量表检查,并完成定量脑电图监测,计算δ波功率值及(δ+θ)/(α+β)比值(DTABR),并进行相关统计分析。结果颞叶癫痫认知障碍组患者40例,男性23例(占57.5%),女性17例(占42.5%),平均年龄(48.15±14.85),平均受教育年限(9.43±2.50),平均用药年限(8.35±4.55);对照组40例患者中男性21例(占52.5%),女性19例(占47.5%),平均年龄(50.83±15.58),平均受教育年限(9.45±2.45),平均用药年限(9.23±5.14)。认知障碍组和正常对照组在年龄、性别、文化程度、用药年限等方面差异无统计学意义(P>0.05),颞叶癫痫患者认知障碍组和正常对照组Moca评分分别为5~25(21.00±7.00)分和26~29(27.00±2.00)分,两组比较差异有统计学意义(Z=-7.738,P<0.05)。认知障碍组δ波功率值及DTABR均显著高于认知正常对照组(均P<0.05);颞叶癫痫患者认知功能测试指标和QEEG电功率DTABR具有相关性,认知功能测试指标与δ波功率值、DTABR均呈负相关(P<0.05),而δ波功率值与DTABR呈正相关(P<0.05)。结论颞叶癫痫患者QEEG中慢波与认知障碍存在相关性,提示DTABR可以作为颞叶癫痫患者认知功能筛查的电功率指标。

Objective To investigate the correlation of slow wave on quantitative electroencephalography(QEEG)with cognitive dysfunction.Methods A total of 80 patients with temporal lobe epilepsy who attended The Affiliated Hospital of Chifeng University from January to October 2022 were collected.All patients underwent Montreal Cognitive Assessment(MoCA)and QEEG monitoring to calculateδwave power and(δ+θ)/(α+β)ratio(DTABR),and statistical analyses were performed.Results There were 40 patients in the temporal lobe epilepsy+cognitive dysfunction group,among whom there were 23 male patients(57.5%)and 17 female patients(42.5%),with a mean age of(48.15±14.85)years,a mean duration of education of 9.43±2.5 years,and a mean duration of medication of 8.35±4.55 years;there were 40 patients in the control group,among whom there were 21 male patients(52.5%)and 19 female patients(47.5%),with a mean age of 50.83±15.58 years,a mean duration of education of 9.45±2.45 years,and a mean duration of medication of 9.23±5.14 years.There were no significant differences in age,sex,education level,and medication years between the cognitive dysfunction group and the normal control group(P>0.05),and there was a significant difference in MoCA score between the cognitive dysfunction group and the normal control group[21±7(5-25)points vs 27±2(26-29)points,Z=-7.738,P<0.05].The cognitive dysfunction group had significantly higherδwave power and DTABR than the normal control group(P<0.05).In the patients with temporal lobe epilepsy,cognitive function parameters were correlated with electric power and DTABR on QEEG;cognitive function parameters were negatively correlated withδwave power and DTABR(P<0.05),whileδwave power was positively correlated with DTABR(P<0.05).Conclusion There is a correlation between slow wave and DTABR on QEEG in patients with temporal lobe epilepsy,suggesting that DTABR can be used as an electric power indicator for cognitive function screening in patients with temporal lobe epilepsy.