非小细胞肺癌脑转移研究进展

Research progress in brain metastasis of non-small cell lung cancer

非小细胞肺癌是发病率及致死率都位居前列的恶性肿瘤,而脑转移的发生发展严重影响肺癌患者的生活质量及预后。近年来,随着肿瘤研究的不断深入和新药研发快速进展,以靶向治疗和免疫治疗为代表的治疗方案在肺癌脑转移的临床治疗中取得了长足的进步,但也面临后线治疗手段缺乏,长期生存证据不足等问题。在肺癌治疗关口整体前移的大背景下,早期识别和干预脑转移,应该需要更多深入的探索。与此同时,提高临床试验中脑转移患者的比例,以期更贴近临床实践场景,加强非小细胞肺癌脑转移预测和预后的生物标志物研究,都将对脑转移的治疗起到极大的启示和推进作用。

Lung cancer ranks the top malignant tumor with high incidence rate and mortality,while the occurrence and development of brain metastasis influence the quality of life and long-term prognosis seriously.Recently,with the development of new drug research and tumor investigation,targeted and immunotherapy have made great progress in the clinical treatment of brain metastasis,but also face the problems that lack of further-line treatment and long-term survival evidence.Under the background that the threshold of lung cancer treatment moves forward,early identification and intervention of brain metastasis require more in-depth exploration.At the same time,increasing the proportion of patients with brain metastasis in clinical trials to mimic the clinical practice scene,and strengthening the research on biomarkers for predicting brain metastasis and prognosis of non-small cell lung cancer,which would play a pivot role in the treatment of brain metastasis.