脱落酸对诱导多能干细胞巨核系血小板分化的影响

Effect of Abscisic Acid on the Generation of Megakaryocytes and Platelets from Induced Pluripotent Stem Cells in vitro Differentiation

脱落酸作为一种植物激素,具有抑制植物生长、促进果实成熟和落叶的作用,还可影响动物胚胎发育中核苷合成,发挥抑制肿瘤细胞增殖诱导分化和凋亡的重要作用。研究发现脱落酸对人诱导多能干细胞体外诱导分化生产巨核细胞和血小板也有作用,添加不同剂量的脱落酸,影响体外分化产生造血干细胞、造血祖细胞、巨核细胞和血小板的数量。脱落酸对人诱导多能干细胞体外巨核系血小板分化的相关作用及可能的机制研究对诱导多能干细胞体外大规模分化产生血小板,缓解临床尤其是血小板输注无效患者的血小板供应有重要意义。

Abscisic acid is a plant hormone,which can inhibit plant growth,promote fruit ripening and defoliation.ABA can affect nucleoside synthesis during animal embryo development,and play an important role in inhibiting tumor cell proliferation,by means of inducing differentiation and apoptosis.Studies have shown that ABA stimulates the production of megakaryocyte and platelet differentiation from human induced pluripotent stem cells in vitro.ABA can affect the number of hematopoietic stem cells,hematopoietic progenitor cells,megakaryocytes and platelets generation from hiPSCs in vitro system.The study on the related effect and underlying mechanism of ABA on megakaryocyte and platelet differentiation from human induced pluripotent stem cells in vitro is of great significance for the production of platelets by large-scale to meet the needs of platelet transfusion in clinical especially for platelet transfusion refractoriness.