雷贝拉唑、左氧氟沙星、阿莫西林联合胶体果胶铋治疗幽门螺杆菌阳性患者的临床观察

Clinical Observation of Rabeprazole+Levofloxacin+Amoxicillin+Colloidal Bismuth Pectin in Treatment of Helicobacter Pylori Positive Patients

目的:分析两种四联疗法治疗幽门螺杆菌阳性患者的临床效果。方法:选取2019年1月—2022年3月上海市嘉定区嘉定镇街道社区卫生服务中心收治的120例幽门螺杆菌阳性患者作为研究对象,采用随机数字表法分为对照组与观察组,各60例。对照组采用克拉霉素、雷贝拉唑、胶体果胶铋联合阿莫西林进行治疗,观察组采用雷贝拉唑、左氧氟沙星、阿莫西林联合胶体果胶铋进行治疗。比较两组幽门螺杆菌根除率、治疗效果、不良反应发生情况。结果:观察组幽门螺杆菌根除率高于对照组,差异有统计学意义(P=0.002)。观察组不良反应总发生率低于对照组,差异有统计学意义(P=0.015)。观察组治疗总有效率高于对照组,差异有统计学意义(P=0.006)。结论:幽门螺杆菌阳性患者采用雷贝拉唑、左氧氟沙星、阿莫西林联合胶体果胶铋的四联疗法进行干预,能够提高幽门螺杆菌根除率,治疗效果显著,且不良反应发生率低。

Objective:To analyze the clinical effect of two quadruple therapies on treating Helicobacter pylori positive patients.Methods:A total of 120 Helicobacter pylori positive patients who were treated in Shanghai Jiading District Jiading Town Street Community Health Service Center from January 2019 to March 2022 were selected as the study subjects.They were divided into control group and observation group according to random number table method,with 60 cases in each group.The control group was treated with clarithromycin+rabeprazole+colloidal bismuth pectin+amoxicillin,and the observation group was treated with rabeprazole+levofloxacin+amoxicillin+colloidal bismuth pectin.The eradication rate of Helicobacter pylori,treatment effect and adverse reactions in two groups were compared.Results:The eradication rate of Helicobacter pylori in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.002).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.015).The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.006).Conclusion:The intervention of quadruple therapy of rabeprazole+levofloxacin+amoxicillin+colloidal bismuth pectin in Helicobacter pylori positive patients can increase the eradication rate of Helicobacter pylori,the treatment effect is significant,and the the incidence of adverse reactions is low.