卡前列素氨丁三醇与缩宫素治疗宫缩乏力性产后出血患者的效果分析

Effect Analysis of Carboprost Tromethamine and Oxytocin in Treatment of Patients with Postpartum Hemorrhage Caused by Uterine

目的:探讨卡前列素氨丁三醇与缩宫素治疗宫缩乏力性产后出血患者的效果。方法:选取2021年4月—2022年11月菏泽市第六人民医院收治的86例宫缩乏力性产后出血患者作为研究对象,根据随机数字表法分为对照组与试验组,各43例。对照组采用缩宫素治疗,试验组在对照组基础上采用卡前列素氨丁三醇治疗。比较两组凝血功能、产后出血量、子宫底高度、治疗效果及不良反应发生情况。结果:治疗后,试验组凝血酶时间、凝血酶原时间、活化部分凝血活酶时间长于对照组,纤维蛋白原、D-二聚体水平低于对照组,差异有统计学意义(P<0.05)。产后2、12、24h,试验组出血量少于对照组,差异有统计学意义(P<0.001)。产后1、3、5d,试验组子宫底高度低于对照组,差异有统计学意义(P<0.001)。试验组治疗总有效率高于对照组,差异有统计学意义(P=0.007)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:卡前列素氨丁三醇与缩宫素联合治疗宫缩乏力性产后出血患者可获得良好的效果,对凝血功能具有积极影响,可减少产后出血量,且安全性较高。

Objective:To investigate the effect of carboprost tromethamine and oxytocin in the treatment of patients with postpartum hemorrhage caused by uterine atony.Methods:A total of 86 patients with postpartum hemorrhage due to uterine atony admitted to Heze Sixth People's Hospital from April 2021 to November 2022 were selected as the study subjects.According to the random number table method,they were divided into control group and experimental group,with 43 cases in each group.The control group was treated with oxytocin,and the experimental group was treated with carboprost tromethamine on the basis of the control group.The blood coagulation function,postpartum hemorrhage volume,uterine fundus height,treatment effect and adverse reactions in the two groups were compared.Results:After treatment,the thrombin time,prothrombin time and activated partial thromboplastin time in the experimental group were longer than those in the control group,and the levels of fibrinogen and D-dimer in the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).At postpartum 2 h,12 h and 24 h,the blood loss in the experimental group was less than that in the control group,and the difference was statistically significant(P<0.001).At postpartum 1 d,3 d and 5 d,the uterine fundus height in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.001).The total effective rate of treatment in the experimental group was higher than that in the control group,and the difference was statistically significant(P=0.007).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of carboprost tromethamine and oxytocin in the treatment of patients with postpartum hemorrhage caused by uterine atony can achieve good results,have a positive effect on blood coagulation function,reduce postpartum hemorrhage volume,and have a high safety.