替雷利珠单抗联合贝伐珠单抗治疗Ⅳ期肺腺癌的效果分析

Effect Analysis of Tislelizumab Combined with Bevacizumab in Treatment of StageⅣLung Adenocarcinoma

目的:探讨替雷利珠单抗联合贝伐珠单抗治疗Ⅳ期肺腺癌的效果。方法:选取2020年8月—2022年8月广西壮族自治区南溪山医院收治的100例Ⅳ期肺腺癌患者作为研究对象,随机分为对照组与研究组,各50例。对照组应用替雷利珠单抗治疗,研究组在对照组基础上应用贝伐珠单抗治疗,比较两组治疗效果。结果:研究组治疗总有效率高于对照组,差异有统计学意义(P=0.019)。研究组不良反应总发生率低于对照组,差异有统计学意义(P=0.012)。治疗后,研究组自然杀伤细胞、CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)水平高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05)。治疗后,研究组血管内皮生长因子水平低于对照组,差异有统计学意义(P=0.009)。结论:替雷利珠单抗联合贝伐珠单抗治疗Ⅳ期肺腺癌的效果显著,能够抑制患者肿瘤进展,提高免疫功能,降低肿瘤标志物水平及不良反应发生率。

Objective:To investigate the effect of tislelizumab combined with bevacizumab in the treatment of stage IV lung adenocarcinoma.Methods:A total of 100 patients with stage IV lung adenocarcinoma admitted to Nanxishan Hospital of Guangxi Zhuang Autonomous Region from August 2020 to August 2022 were selected as the study subjects.They were randomly divided into control group and study group,with 50 cases in each group.The control group was treated with tislelizumab,and the study group was treated with bevacizumab on the basis of the control group.The treatment effects of the two groups were compared.Results:The total effective rate of treatment in the study group was higher than that in the control group,and the difference was statistically significant(P=0.019).The total incidence of adverse reactions in the study group was lower than that in the control group,and the difference was statistically significant(P=0.012).After treatment,the levels of natural killer cells,CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)in the study group were higher than those in the control group,and the levels of CD8+in the study group were lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the level of vascular endothelial growth factor in the study group was lower than that in the control group,and the difference was statistically significant(P=0.009).Conclusion:Tislelizumab combined with bevacizumab has a significant effect in the treatment of stage IV lung adenocarcinoma,it can inhibit tumor progression,improve immune function,reduce the level of tumor markers and the incidence of adverse reactions.