硝苯地平联合阿司匹林肠溶片治疗妊娠高血压的效果观察

Effect Observation of Nifedipine Combined with Aspirin Enteric-Coated Tablet in Treatment of Gestational Hypertension

目的:探讨硝苯地平联合阿司匹林肠溶片治疗妊娠高血压的效果。方法:选取2021年5月—2022年5月宁乡市人民医院收治的86例妊娠高血压患者作为研究对象,根据抽签法分为参照组与试验组,各43例。参照组采用硝苯地平治疗,试验组在参照组基础上应用阿司匹林肠溶片。比较两组凝血功能、血压水平、生活质量评分、症状积分及不良妊娠结局发生情况。结果:治疗后,试验组凝血酶原时间、活化的部分凝血活酶时间长于参照组,血浆纤维蛋白原、收缩压、舒张压水平低于参照组,差异有统计学意义(P<0.05)。治疗后,试验组搏动指数、阻力指数、收缩期峰值/舒张期峰值低于参照组,差异有统计学意义(P<0.001)。治疗后,试验组躯体功能、物质生活、生理功能、心理功能、情感职能、总体健康评分高于参照组,差异有统计学意义(P<0.001)。治疗后,试验组水肿、头晕、肢体麻木、失眠、腰膝酸痛、耳鸣积分低于参照组,差异有统计学意义(P<0.001)。试验组不良妊娠结局总发生率低于参照组,差异有统计学意义(P=0.024)。结论:硝苯地平联合阿司匹林肠溶片治疗妊娠高血压,可提高患者血压控制的效果,并且能够改善临床症状、凝血功能、生活质量,降低不良妊娠结局发生率。

Objective:To explore the effect of nifedipine combined with aspirin enteric-coated tablet in the treatment of gestational hypertension.Methods:A total of 86 patients with gestational hypertension admitted to Ningxiang People's Hospital from May 2021 to May 2022 were selected as the study subjects.According to the lottery method,they were divided into a reference group and an experimental group,with 43 cases in each group.The reference group was treated with nifedipine,and the experimental group was treated with aspirin enteric-coated tablet on the basis of the reference group.Coagulation function,blood pressure levels,quality of life scores,symptom scores,and adverse pregnancy outcomes were compared between the two groups.Results:After treatment,the prothrombin time and activated partial thromboplastin time in the experimental group were longer than those in the reference group,and the plasma fibrinogen,systolic blood pressure and diastolic blood pressure levels in the experimental group were lower than those in the reference group,and the differences were statistically significant(P<0.05).After treatment,the pulsatility index,resistance index,systolic peak/diastolic peak in the experimental group were lower than those in the reference group,and the difference was statistically significant(P<0.001).After treatment,the physical function,material life,physiological function,psychological function,emotional function,and overall health scores in the experimental group were higher than those in the reference group,and the difference was statistically significant(P<0.001).After treatment,the scores of edema,dizziness,limb numbness,insomnia,waist and knee ache,and tinnitus in the experimental group were lower than those in the reference group,and the difference was statistically significant(P<0.001).The overall incidence of adverse pregnancy outcomes in the experimental group was lower than that in the reference group,and the difference was statistically significant(P=0.024).Conclusion:Nifedipine combined with aspirin enteric-coated tablet in the treatment of gestational hypertension can improve the effect of blood pressure control,improve clinical symptoms,coagulation function,quality of life,and reduce the incidence of adverse pregnancy outcomes.