基于CiteSpace的心肌细胞增殖研究热点的可视化分析

Visualization analysis of research hotspots of cardiomyocyte proliferation based on CiteSpace

目的分析我国近十年心肌细胞增殖研究领域的发展情况,探索其研究概况、研究热点及前沿。方法检索中国知网数据库中发表于2012年1月1日至2022年7月12日关于心肌细胞增殖的相关文献,应用信息可视化软件CiteSpace对发文作者、研究机构、关键词等方面进行可视化分析。结果本研究共纳入有效文献1597篇,年度发文量总体呈上升趋势。发文量前5位的作者分别为鲍翠玉、田振军、严李程、刘涛、李晶,且合作较为密切。发文量前5位的研究机构分别为湖北科技学院糖尿病心脑血管病变湖北省重点实验室、湖北科技学院药学院、河南中医学院第一附属医院、河南医学高等专科学校、中国中医科学院广安门医院。共抽取关键词420个,关键词累计总频次达2913次。在该研究领域中除主题词外出现频次最高的关键词为凋亡;同时,国内的研究形成的关键词共现网络分别以细胞增殖、细胞凋亡、氧化应激、信号通路、干细胞等为中心展开。研究通过关键词时间线图谱发现,国内心肌细胞增殖领域研究在2012年后迎来了快速发展阶段,但近些年的研究热点较前更为集中,在演进过程中分为心脏、心肌损伤、高糖、增殖、心肌梗死等十一个聚类;研究领域已经形成一定规模,心肌细胞增殖领域的热点随着时间迁移越来越细节化,心肌细胞增殖研究的重心从前期的心肌细胞再生、细胞凋亡转向了血管生成。结论心肌细胞增殖领域研究处于快速发展时期,血管内皮细胞再生是其未来研究的重点方向,未来需加强不同研究机构之间跨区域的合作交流,扩大研究成果,提高研究效能。

Objective To analyze the development of cardiomyocyte proliferation research in China in the past decade,and explore its research overview,research hotspots and frontiers.Methods The related literatures on cardiomyocyte proliferation published from January 1,2012 to July 12,2022 in the database of CNKI were searched.The information visualization software CiteSpace was used to visually analyze the author,research institution,keywords and other aspects of the articles.Results A total of 1597 effective literatures were included in this study,and the annual number of articles was on the rise.The top five authors in the number of articles were Bao Cuiyu,Tian Zhenjun,Yan Licheng,Liu Tao,and Li Jing,and they cooperated closely.The top 5 research institutions in the number of published documents were the Hubei Provincial Key Laboratory of Diabetes Cardio Cerebrovascular Disease of Hubei University of Science and Technology,the School of Pharmacy of Hubei University of Science and Technology,the First Affiliated Hospital of Henan University of traditional Chinese Medicine,Henan Medical College,and Guang'anmen Hospital of Chinese Academy of Traditional Chinese Medicine.A total of 420 keywords were extracted,and the cumulative total frequency of keywords reached 2913 times.In this research field,the keyword with the highest frequency except for the subject words was apoptosis.At the same time,the keyword co-occurrence network formed by domestic research focuses on cell proliferation,apoptosis,oxidative stress,signaling pathways,stem cells.According to the keyword timeline map,the research in the field of cardiomyocyte proliferation in China had ushered in a rapid development stage after 2012,but the research hotspots in recent years were more concentrated than before.In the evolution process,it was divided into 11 clusters,such as heart,myocardial injury,high glucose,proliferation,and myocardial infarction.The research field had formed a certain scale,and the hot spots in the field of cardiomyocyte proliferation become more and more detailed with the time migration.The focus of cardiomyocyte proliferation research has shifted from cardiomyocyte regeneration and apoptosis to angiogenesis.Conclusion The research field of cardiac cell proliferation is in a period of rapid development,and the regeneration of vascular endothelial cells is the key direction of its future research.In the future,it is necessary to strengthen the cross-regional cooperation and exchange between different research institutions,expand the research results,and give full play to the research efficiency.