闫雪洁教授运用扶正降浊解毒方治疗溃疡性结肠炎经验

Professor YAN Xuejie’s experience in treating ulcerative colitis with Fuzheng Jiangzhuo Jiedu formula

溃疡性结肠炎具有治疗困难、易复发、缓慢持续进展、伴有多种并发症甚至癌变的特点,近年溃疡性结肠炎的发病率在世界范围内逐年上升,与此相关联的结直肠癌的发病率呈同步升高态势,可见,尽早研究安全有效治疗该病的方法意义重大。溃疡性结肠炎的发病机制尚未完全明确,临床缺少治疗该病的特效药物,多用氨基水杨酸类药物、肾上腺皮糖质激素、免疫抑制剂等药物治疗,症状多能有所改善,但需长期服药,且进展缓慢、易反复发作,往往给患者带来巨大的经济和心理压力,不利于疾病向愈。吾师闫雪洁教授辨证论治经验丰富,对本病有独到见解,临床用口服中药汤剂结合西药的方案治疗本病,疗效显著且复发率大大降低。文章以“扶正降浊解毒法治疗溃疡性结肠炎经验”为题综合论述,从中西医两个角度对本病病因病机进行分析,详细阐明扶正降浊解毒方的组成及方解,从中医中药四气五味主治功效及西医生物分子药理学两个方面论述扶正降浊解毒方的科学依据,分享临床典型病例,详述辨病辨证依据、选方用药思路,旨在为临床提供研究资料和治疗经验。

Ulcerative colitis has the characteristics of difficult treatment,easy relapse,slow and continuous progress,accompanied by multiple complications and even canceration.In recent years,the incidence rate of ulcerative colitis has increased year by year in the world,and the incidence rate of colorectal cancer associated with it has been increasing simultaneously.Therefore,it is of great significance to study the safe and effective treatment of this disease as soon as possible.The pathogenesis of ulcerative colitis has not been fully defined,and there is a lack of specific drugs for the treatment of the disease in clinic.Amino salicylic acid drugs,adrenal glucose-hormone,immunosuppressants and other drugs are used to treat the disease.Most symptoms can be relieved,but long-term medication is needed,and the progress is slow and easy to relapse,which often brings huge economic and psychological pressure to patients,and it is not conducive to the recovery of the disease.The mentor,Professor YAN Xuejie,has unique insights into this disease and rich experience in syndrome differentiation and treatment.The combination of oral traditional Chinese medicine decoction and Western medicine has achieved remarkable curative effect and greatly reduced the recurrence rate in the clinical treatment of this disease.The paper comprehensively discusses the topic of“experience of Fuzheng Jiangzhuo Jiedu(扶正降浊解毒)method in treating ulcerative colitis”,analyzes the etiology and pathogenesis of this disease from the perspectives of traditional Chinese medicine and Western medicine,and expounds the composition and solution of Fuzheng Jiangzhuo Jiedu formula(扶正降浊解毒方)in detail.The paper discusses the scientific basis of Fuzheng Jiangzhuo Jiedu formula from the two aspects of the efficacy of four tastes and five flavors of traditional Chinese medicine and the biological molecular pharmacology of Western medicine,shares the typical clinical cases,details the basis of disease differentiation and the thinking of prescription selection,so as to provide research data and treatment experience for the clinic.