替罗非班与阿司匹林在支架下颅内宽颈动脉瘤治疗后的应用疗效对比

Comparison of Efficacy of Tirofiban and Aspirin in the Treatment of Intracranial Wide-neck Aneurysms under Stent

目的研究替罗非班与阿司匹林对支架下颅内宽颈动脉瘤治疗后患者的影响。方法方便选取2020年1月—2021年2月漳州市第二医院接收的颅内宽颈动脉瘤患者96例为研究对象,以随机列表法进行分组,各48例,两组均接受支架下颅内宽颈动脉瘤治疗,而治疗后研究组服用替罗非班,对照组服用阿司匹林,比较两组的总有效率、活化部分凝血活酶时间(APTT)、血小板计数(PLT)、不良反应(颅内出血、迟发性缺血、局限性脑梗死)及生活质量(QOL)评分。结果研究组总有效率91.67%高于对照组75.00%,差异有统计学意义(χ^(2)=4.800,P<0.05)。两组服药前后APTT、PLT比较,差异无统计学意义(P>0.05)。研究组不良反应发生率6.25%低于对照组的20.83%,差异有统计学意义(P<0.05)。服药前两组QOL评分比较,差异无统计学意义(P>0.05),服药后研究组QOL评分高于对照组,差异有统计学意义(P<0.05)。结论替罗非班在支架下颅内宽颈动脉瘤治疗后中的应用效果更好,不良反应少,可提升患者生活质量。

Objective To investigate the effects of tirofiban and aspirin on patients with intracranial wide-neck aneurysms treated under stent.Methods 96 patients with intracranial wide necked aneurysms received by the Second Hospital of Zhangzhou City from January 2020 to February 2021 were conveniently selected as the study subjects.They were grouped by random listing method,with 48 patients in each group.Both groups received stent assisted treatment for intracranial wide necked aneurysms.After treatment,the study group took tirofiban,and the control group took aspirin.The total effective rate,activated partial thromboplastin time(APTT),platelet count(PLT)Adverse reactions(Intracranial hemorrhage,delayed ischemia,localized cerebral infarction)and quality of life(QOL)scores.Results The total effective rate of the research group was 91.67%,higher than that of the control group of 75.00%,the difference was statistically significant(χ^(2)=4.800,P<0.05).There was no statistically significant difference in APTT and PLT between the two groups before and after medication(P>0.05).The incidence of adverse reactions in the study group was 6.25%,lower than 20.83%in the control group,the difference was statistically significant(P<0.05).Before taking the medication,there was no statistically significant difference in QOL scores between the two groups(P>0.05).After taking the medication,the QOL scores of the study group were higher than those of the control group,the difference was statistically significant(P<0.05).Conclusion The application of tirofiban in the treatment of intracranial wide necked aneurysms under stent has better efficacy,fewer adverse reactions,and can improve the quality of life of patients.