咪唑并[1,2-a]吡啶C-C键偶联反应研究进展

Research Progress on C-C Bond Coupling Reactions of Imidazo[1,2-a]pyridine

咪唑并[1,2-a]吡啶衍生物具有较强的药物活性,是一类非常重要的含氮稠杂环化合物,因其特殊结构和良好的生物活性,在药物合成反面有广泛应用,成为许多研究人员的关注重点。本文将以咪唑并[1,2-a]吡啶为原料,以C(sp^(2))-C(sp3)键偶联、C(sp^(2))-C(sp^(2))键偶联和C(sp^(2))-C(sp)键偶联三种偶联反应为例,分别介绍了近几年咪唑并[1,2-a]吡啶类化合物在C-3位的C-H键活化构建C-C键偶联反应研究进展。

Imidazo[1,2-a]pyridine derivatives have strong pharmaceutical activity and are a very important class of nitrogen-containing thick heterocyclic compounds,which are widely used in the reverse side of drug synthesis due to their special structures and good biological activities,and have become the focus of many researchers'attention.Three coupling reactions,C(sp^(2))-C(sp3)bond coupling,C(sp^(2))-C(sp^(2))bond coupling and C(sp^(2))-C(sp)bond coupling,would be used as the raw materials of imidazo[1,2-a]pyridines,and the progress of C-H bond activation at the C-3 position for the construction of C-C bond coupling reactions of imidazo[1,2-a]pyridines would be introduced respectively in recent years.