糖尿病周围神经病变与病程、2 h CP、Cys-C、UACR的相关性

Correlation between diabetic peripheral neuropathy and course of disease,2 h CP,Cys⁃C,UACR

目的探讨胱抑素C(Cys-C)、餐后2小时C肽(2 h CP)、尿微量白蛋白/尿肌酐(UACR)、病程与2型糖尿病周围神经病变(DPN)的相关性。方法根据双下肢肌电图及足部定量感觉检查结果,选取庆阳市人民医院2021年1月至2022年1月的DPN患者100例作为观察组、2型糖尿病非周围神经病变(NDPN)患者73例作为对照组,收集患者的实验室数据及临床指标,分析Cys-C、2 h CP、UACR、病程等指标与DPN之间的相关性。结果DPN组空腹胰岛素(FINS)、尿免疫球蛋白G、尿肌酐、病程、Cys-C、UACR均显著高于NDPN组,差异有统计学意义(t=-2.728,-3.826,-2114,-2.632,-2.850,-2.717,P<0.05);2 h CP水平显著低于NDPN组,差异有统计学意义(t=2.696,P<0.05);Logisitc回归显示,糖尿病病程、2 h CP、Cys-C与DPN具有相关性,差异有统计学意义(OR=1.863,0.729,3.799,P<0.05);ROC曲线显示,病程、Cys-C、2 h CP、糖化血红蛋白(HbA1c)四项联合的诊断性能较好,其次是Cys-C。结论Cys-C、2 h CP、UACR、病程与DPN相关,可能是疾病发作的危险性因素,临床需对此引起高度重视。

Objective To investigate the correlation between cystatin C(Cys⁃C),2 hours postpran⁃dial C peptide(2 h CP),urinary microalbumin/urinary creatinine(UACR),disease duration and type 2 diabetic peripheral neuropathy(DPN).Methods According to the results of lower limb electromyography and foot quantitative sensory examination,100 DPN patients(observation group)and 73 patients(control group)with type 2 diabetes and non⁃peripheral neuropathy(NDPN)were selected from the People's Hospital of Qingyang City from January 2021 to January 2022.Laboratory data and clinical indicators of patients were collected.The correlation between DPN and Cys⁃C,2 h CP,UACR,disease course and other indicators was analyzed.Results Fasting insulin(FINS),urinary immunoglobulin G,urinary creatinine,disease course,Cys⁃C and UACR in the DPN group were significantly higher than those in the NDPN group,and the difference was statis⁃tical significance(t=-2.728,-3.826,-2114,-2.632,-2.850,-2.717,P<0.05).The levels of 2 h CP were sig⁃nificantly lower than those of the NDPN group,and the difference was statistical significance(t=2.696,P<0.05).Logisitc regression showed that the duration of diabetes,2 h CP and Cys⁃C were correlated with DPN,and the difference was statistical significance(OR=1.863,0.729,3.799,P<0.05).The ROC curve showed that the combination of disease course,Cys⁃C,2h CP,and HbA1c had better diagnostic performance,followed by Cys⁃C.Conclusions Cys⁃C,2 h CP,UACR,and course of disease are related to DPN,which may be risk factors of disease onset and clinical attention should be paid to them.