绝经后女性脑梗死后疲劳与性激素、Cys-C、CRP水平的相关性

Correlation between post⁃stroke fatigue and sex hormones,Cys⁃C,CRP in postmenopausal women

目的分析绝经后女性脑梗死后疲劳(PSF)与性激素、Cys-C、CRP水平的相关性。方法选取2020年5月至2022年9月期间北京世纪坛医院神经科收治的134例绝经后女性脑梗死患者的临床资料,将其中56例PSF患者作为PSF组,78例非PSF患者作为非PSF组,并同期选取134名行体检的健康绝经后女性为对照组,比较三组女性的血清性激素[E_(2)、FSH、LH、PRL、P、T]、Cys-C、CRP水平,并分析性激素、Cys-C、CRP水平与PSF严重程度[FSS评分]的相关性、对绝经后女性PSF的预测价值以及绝经后女性PSF发生的独立危险因素。结果PSF组、非PSF组女性的血清E_(2)、FSH、LH、PRL、P、T水平均低于对照组,而Cys-C、CRP水平均高于对照组,差异有统计学意义(P<0.05);PSF组血清E_(2)、T水平低于非PSF组,Cys-C、CRP水平高于非PSF组,差异有统计学意义(P<0.05);Spearman相关分析显示,血清E_(2)、T水平与FSS评分呈负相关,血清Cys-C、CRP水平与FSS评分呈正相关(P<0.05);ROC曲线结果显示,血清E_(2)、T、Cys-C、CRP水平预测绝经后女性PSF发生的AUC分别为0.829、0.795、0.788、0.852;Logistic回归分析显示,血清E_(2)≤74.52 pmol/L、T≤0.815 nmol/L、Cys-C≥1.715 mg/L、CRP≥10.74 mg/L是绝经后女性PSF发生的独立危险因素(P<0.05)。结论绝经后女性PSF与血清性激素E_(2)、T、Cys-C、CRP水平有密切的相关性,血清E_(2)、T、Cys-C、CRP水平变化是PSF发生的独立危险性因素,对PSF临床预测有一定的价值。

Objective To analyze the correlation between post⁃stroke fatigue(PSF)and sex hormones,Cys⁃C,CRP in postmenopausal women.Methods A retrospective analysis was performed on the clinical data of 134 postmenopausal women with cerebral infarction admitted to the Neurology Department of Beijing Shijitan Hospital between May 2020 and September 2022,including 56 cases with PSF in the PSF group and 78 cases without PSF in the non⁃PSF group.A total of 134 healthy postmenopausal women undergoing physical examination during the same period were enrolled as the control group.The levels of serum sex hormones[E_(2),FSH,LH,PRL,P,T],Cys⁃C and CRP in the three groups were compared.The correlation between sex hormones,Cys⁃C,CRP levels and the severity of PSF[Fatigue Severity Scale(FSS)]was analyzed by Spearman correlation coefficient.The predictive value of sex hormones,Cys⁃C and CRP for PSF was analyzed by the ROC curves.The independent risk factors of PSF were analyzed by Logistic multivariate regression analysis.Results The levels of serum E_(2),FSH,LH,PRL,P and T in the PSF group and the non⁃PSF group were lower than those in the control group,while levels of Cys⁃C and CRP were higher than those in the control group(P<0.05).The levels of serum E_(2) and T in the PSF group were lower than those in the non⁃PSF group,while levels of Cys⁃C and CRP were higher than those in the non⁃PSF group(P<0.05).Spearman correlation analysis showed that levels of serum E_(2) and T were negatively correlated with FSS score,while levels of serum Cys⁃C and CRP were positively correlated with it(P<0.05).The results of ROC curves analysis showed that the AUC of serum E_(2),T,Cys⁃C and CRP for predicting PSF were 0.829,0.795,0.788,0.852 respectively.Logistic regression analysis showed that serum E_(2)≤74.52 pmol/L,T≤0.815 nmol/L,Cys⁃C≥1.715 mg/L and CRP≥10.74 mg/L were independent risk factors of PSF in postmenopausal women(P<0.05).Conclusion There is a close correlation between PSF and serum sex hormones E_(2),T,Cys⁃C,and CRP levels in postmenopausal women.Changes in serum E_(2),T,Cys⁃C,and CRP levels are independent risk factors for the occurrence of PSF,and have certain implications for the clinical prediction of PSF.