自噬在IgA肾病发病机制中的研究进展

Progress in autophagy in the pathogenesis of IgA nephropathy

IgA肾病(IgAN)是一种自身免疫性肾脏疾病,也是发病率最高的原发性肾小球肾炎,探索IgAN发病机制及治疗策略的研究具有重大意义。自噬是维持细胞正常功能和结构的一个基本的细胞过程,本文就自噬在IgA肾病发病机制中的研究进展进行综述。目前的研究发现,自噬抑制可导致IgAN系膜细胞增殖、足细胞丢失、肾小球硬化等,影响着IgAN的发生和进展。

IgA nephropathy(IgAN)is an autoimmune kidney disease with the highest incidence of primary glomerulonephritis.It is of great significance to explore the pathogenesis of IgAN and its therapeutic strategies for treatment.Autophagy is a basic cellular process that maintains the normal function and structure of cells,recycling nutrients,removing damaged organelles and protein aggregates,and eliminating invading pathogens.The current study found that autophagy inhibition can lead to the proliferation of IgAN mesangial cells,podocyte loss,and glomerular sclerosis,which affects the occurrence and progression of IgAN.