中药调控p38丝裂原活化蛋白激酶/核因子κB通路治疗肾纤维化研究进展

Research progress of traditional Chinese medicine regulating p38MAPK/NF-κB pathway in treatment of renal fibrosis

肾纤维化是一种慢性、动态且不可逆的病理改变,是慢性肾脏病进展的主要病理过程。p38丝裂原活化蛋白激酶/核因子κB(p38MAPK/NF-κB)信号参与炎症反应及氧化应激,在肾纤维化进展中发挥关键的调控作用。近年来中药通过靶向调控氧化应激及相关信号通路防治肾纤维化成为研究热点。研究表明单味中药及中药复方有效成分通过调控p38MAPK/NF-κB信号改善氧化应激损伤和炎症状态,发挥保护肾脏功能作用,且临床疗效较好。通过归纳中药调控p38MAPK/NF-κB信号通路干预肾纤维化机制的研究,为中医药防治本病提供参考。

Renal fibrosis is a chronic,dynamic and irreversible pathological change,which is the main pathological process of the progression of chronic kidney disease.p38 mitogen-activated protein kinase/nuclear factor-κB(p38MAPK/NF-κB)signaling is involved in inflammatory response and oxidative stress,and plays a key regulatory role in the progression of renal fibrosis.In recent years,traditional Chinese medicine becomed research hotspot in the prevention and treatment of renal fibrosis by targeted regulation of oxidative stress and related signaling pathways.Studies have shown that single traditional Chinese medicine and active ingredients of traditional Chinese medicine compound can improve oxidative stress injury and inflammatory state by regulating p38MAPK/NF-κB signaling play a role in protecting kidney function,and have significant clinical efficacy.Reviews the mechanism of traditional Chinese medicine regulating p38MAPK/NF-κB signaling pathway to intervene renal fibrosis,in order to provide a reference for prevention and treatment of renal fibrosis with traditional Chinese medicine.