丙酮酸脱氢酶激酶4在肝细胞癌中的作用研究进展

Research progress on role of pyruvate dehydrogenase kinase 4 in hepatocellular carcinoma

肝细胞癌(HCC)是全球癌症相关死亡的第三大原因,其发病率继续上升。近年来,癌症代谢在癌症研究中备受关注。细胞代谢的改变是癌症的特征之一。它们不仅是肿瘤进展的结果,也是癌症发生的原因。丙酮酸脱氢酶激酶4(PDK4)是一种关键的代谢酶,通过抑制丙酮酸脱氢酶(PDH)来调节细胞代谢。但PDK4在各种癌症包括HCC的肿瘤发生和进展中的功能和潜在分子机制仍然在很大程度上未知。现就近年来PDK4在HCC中的作用作一综述。

The incidence of hepatocellular carcinoma(HCC),the third most common cause of cancer-related deaths worldwide,is increasing.Cancer research has paid a lot of attention lately to cancer metabolism.Cancer is known to have changes in cellular metabolism as one of its characteristics.They contribute to the growth of cancer as well as being a result of the progression of tumors.Key metabolic enzyme pyruvate dehydrogenase kinase 4(PDK4)controls cellular metabolism by blocking pyruvate dehydrogenase(PDH).However,it is still completely unknown how PDK4 contributes to carcinogenesis and the development of different malignancies,including HCC.A review of the role of PDK4 in HCC in recent years is presented.