硫酸镁联合硝苯地平治疗妊娠期高血压患者中的临床效果

Clinical effect of magnesium sulfate combined with nifedipine in treatment of patients with gestational hypertensive

目的探讨硫酸镁联合硝苯地平治疗妊娠期高血压患者的临床效果。方法选取2019年5月至2020年12月本院收治的90例妊娠期高血压患者作为研究对象,随机分为观察组与对照组,各45例。观察组采用硫酸镁联合硝苯地平治疗,对照组单用硫酸镁治疗,比较两组血压[舒张压(DBP)、收缩压(SBP)]水平、凝血功能[凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)]及分娩结局。结果治疗前,两组SBP、DBP水平及TT、PT、APTT比较差异无统计学意义;治疗后,观察组SBP、DBP低于对照组,TT、PT、APTT均长于对照组,差异有统计学意义(P<0.05)。观察组不良妊娠结局发生率明显低于对照组,差异有统计学意义(P<0.05)。结论应用硫酸镁联合硝苯地平治疗妊娠期高血压患者效果显著,可有效降低血压水平,维持血压稳定,同时能改善凝血功能,降低不良妊娠结局发生率,促进分娩结局改善,保证母婴安全,值得临床推广应用。

Objective To observe the clinical effect of magnesium sulfate combined with nifedipine in treatment of patients with gestational hypertensive.Methods A total of 90 patients with gestational hypertension admitted to our hospital from May 2019 to December 2020 were selected as the research subjects,and they were randomly divided into the observation group and the control group,with 45 cases in each group.The observation group was treated with magnesium sulfate combined with nifedipine,while the control group was treated with magnesium sulfate alone.Blood pressure(diastolic blood pressure[DBP],systolic blood pressure[SBP]),coagulation function(thrombin time[TT],prothrombin time[PT],activated partial thromboplastin time[APTT])and delivery outcome were compared between the two groups.Results Before treatment,there were no significant differences in SBP and DBP levels,TT,PT and APTT between the two groups.After treatment,SBP and DBP in the observation group were lower than those in the control group,while TT,PT and APTT were longer than those in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse pregnancy outcome in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Magnesium sulfate combined with nifedipine in the treatment of patients with gestational hypertension has significant effect,which can effectively reduce the blood pressure level,maintain the stability of blood pressure,improve the coagulation function,reduce the incidence of adverse pregnancy outcomes,improvement of delivery outcomes,ensure the safety of mothers and infants,and is worthy of clinical application.