甲巯咪唑与丙硫氧嘧啶对甲状腺功能亢进患者甲状腺激素指标及肝损伤发生的影响

Effect of methimazole and propylthiouracil on thyroid hormone indices and liver injury in patients with hyperthyroidism

目的探讨甲巯咪唑与丙硫氧嘧啶在甲状腺功能亢进(甲亢)患者中的应用效果。方法选取2018年3月至2021年3月本院收治的112例甲亢患者作为研究对象,按随机数字表法分为两组,各56例。观察组采用甲巯咪唑治疗,对照组采用丙硫氧嘧啶治疗,比较两组临床疗效、甲状腺激素指标、不良反应及肝损伤发生情况。结果观察组治疗总有效率为96.43%,高于对照组的83.93%(P<0.05);治疗后,观察组促甲状腺激素(TSH)水平高于对照组,血清游离甲状腺素(FT4)、血清游离三碘甲腺原氨酸(FT3)水平均低于对照组(P<0.05);观察组不良反应发生率为3.57%,低于对照组的14.29%(P<0.05);观察组肝损伤发生率为5.36%,低于对照组的7.14%(P<0.05)。结论与丙硫氧嘧啶相比,甲巯咪唑治疗甲亢的疗效更佳,能有效改善患者甲状腺激素指标水平,减少肝损伤,且安全性较高,值得临床推广应用。

Objective To investigate the application effect of methimazole and propylthiouracil in patients with hyperthyroidism.Methods 112 patients with hyperthyroidism admitted to our hospital from March 2018 to March 2021 were selected as the research subjects,and they were divided into two groups by random number table method,with 56 cases in each group.The observation group was treated with methimazole,and the control group was treated with propylthiouracil.The clinical efficacy,thyroid hormone indexes,adverse reactions and the occurrence of liver injury were compared between two groups.Results The total clinical effective rate of the observation group was 96.43%,which was higher than 83.93%of control group(P<0.05).After treatment,the thyroid stimulating hormone(TSH)level of the observation group was higher than that of the control group,serum free triiodothyronine(FT3),serum free thyroxine(FT4)level were lower than those of the control group(P<0.05).The incidence of adverse reactions of observation group was 3.57%,which was lower than 14.29%of the control group(P<0.05).The incidence of liver injury of observation group was 5.36%,which was lower than 7.14%of the control group(P<0.05).Conclusion Methimazole is more effective in hyperthyroidism than propylthiouracil,can effectively improve the level of thyroid hormone indicators in patients,reduce liver injury,and with high safety,it is worthy of clinical application.