枸橼酸咖啡因与氨茶碱治疗早产儿呼吸暂停综合征的临床效果对比

Comparison of clinical effects of caffeine citrate and aminophylline in the treatment of apnea syndrome in premature infants

目的对比枸橼酸咖啡因与氨茶碱治疗早产儿呼吸暂停综合征的临床效果。方法选取2018年1月至2019年12月本院收治的60例呼吸暂停综合征患者作为研究对象,随机分为对照组与实验组,每组30例。实验组采取枸橼酸咖啡因治疗,对照组采取氨茶碱治疗,比较两组保温箱内吸氧时间、氧疗总时间、干预后呼吸暂停综合征消失时间、住院总时间及不良反应发生情况。结果实验组保温箱内吸氧时间、氧疗总时间短于对照组,差异有统计学意义(P<0.05)。实验组呼吸暂停综合征消失时间、住院总时间短于对照组,差异有统计学意义(P<0.05)。实验组不良反应发生率为23.33%,低于对照组的36.67%,差异有统计学意义(P<0.05)。结论枸橼酸咖啡因治疗早产儿呼吸暂停综合征疗效显著,可缩短保温箱内吸氧时间、氧疗总时间、呼吸暂停时间及住院总时间,且安全性较高,值得临床推广应用。

Objective To compare the clinical effects of caffeine citrate and aminophylline in the treatment of apnea syndrome in premature infants.Methods 60 patients with apnea syndrome admitted to our hospital from January 2018 to December 2019 were selected as the research subjects,and they were randomly divided into the control group and the experimental group,with 30 cases in each group.The experimental group was treated with caffeine citrate,and the control group was treated with aminophylline,and the oxygen inhalation time in the incubator,the total time of oxygen therapy,the disappearance time of apnea syndrome after intervention,the total length of hospital stay,and the incidence of adverse reactions were compared between the two groups.Results The oxygen inhalation time in the incubator and the total time of oxygen therapy in the experimental group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The disappearance time of apnea syndrome and the total length of hospital stay in the experimental group were shorter than those of the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 23.33%,which was lower than 36.67%in the control group,and the difference was statistically significant(P<0.05).Conclusion Caffeine citrate is effective in the treatment of premature infants with apnea syndrome,which can shorten the oxygen inhalation time in the incubator,the total time of oxygen therapy,the apnea time and the total time of hospitalization,and has high safety,which is worthy of clinical promotion and application.