雌激素联合甲硝唑治疗萎缩性阴道炎临床疗效

Clinical effect of estrogen combined with metronidazole on atrophic vaginitis

目的探讨雌激素联合甲硝唑治疗萎缩性阴道炎临床疗效。方法选取2019年6月至2020年12月本医院收治的150例萎缩性阴道炎患者作为研究对象,随机分为观察组与基础组,每组75例。基础组给予甲硝唑治疗,观察组在基础组的基础上给予戊酸雌二醇治疗。比较两组症状消失时间、子宫内膜厚度、临床疗效、复发率、阴道pH值。结果观察组白带异常、阴道壁充血、阴道瘙痒症状消失时间均短于基础组,差异有统计学意义(P<0.05)。观察组子宫内膜厚度为(2.70±0.40)mm,基础组子宫内膜厚度为(2.80±0.20)mm;两组子宫内膜厚度比较差异无统计学意义。观察组治疗总有效率为98.66%,高于基础组的89.33%,差异有统计学意义(P<0.05)。随访6个月后,观察组复发率为1.33%,低于基础组的12.00%,差异有统计学意义(P<0.05)。治疗后,两组阴道pH值均低于治疗前,且观察组低于基础组,差异有统计学意义(P<0.05)。结论甲硝唑联合戊酸雌二醇治疗萎缩性阴道炎疗效显著,可降低萎缩性阴道炎复发率,改善阴道pH值,值得临床推广应用。

Objective To explore the clinical effect of estrogen combined with metronidazole in treating atrophic vaginitis.Methods 150 patients with atrophic vaginitis admitted to our hospital from June 2019 to December 2020 were selected as the research subjects,and they were randomly divided into observation group and basic group,with 75 cases in each group.The basic group was treated with metronidazole,and the observation group was treated with estrogen on the basis of the basic group.Duration of symptom resolution,endometrial thickness,clinical efficacy,recurrence rate and vaginal pH were compared between the two groups.Results The disappearance time of abnormal leucorrhea,vaginal wall congestion and vaginal pruritus in the observation group were shorter than those in the basic group,and the differences were statistically significant(P<0.05).The endometrial thickness of the observation group was(2.70±0.40)mm,and that of the basic group was(2.80±0.20)mm;there was no significant difference in endometrial thickness between the two groups.The total effective rate of the observation group was 98.66%,which was higher than 89.33%in the base group,and the difference was statistically significant(P<0.05).After 6 months of follow-up,the recurrence rate in the observation group was 1.33%,which was lower than 12.00%in the basic group,and the difference was statistically significant(P<0.05).After treatment,the vaginal pH value in the two groups was lower than before treatment,and the observation group was lower than the basic group,the difference was statistically significant(P<0.05).Conclusion Metronidazole combined with estrogen in the treatment of atrophic vaginitis has significant effect,which can reduce the recurrence rate of atrophic vaginitis and improve vaginal pH value,which is worthy of clinical application.