小儿肺咳颗粒联合盐酸氨溴索对支原体肺炎患儿炎症因子水平的影响

Effect of Xiao'er Feike granule combined with ambroxol hydrochloride on the level of inflammatory factors in children with Mycoplasma pneumonia

目的探讨小儿肺咳颗粒联合盐酸氨溴索对支原体肺炎(MPP)患儿炎症因子水平的影响。方法选取2020年5月至2021年12月于宜春市第二人民医院儿科就诊的90例MPP患儿作为研究对象,按照治疗方案的不同分为对照组与观察组,各45例。对照组在对症治疗基础上采用盐酸氨溴索注射液治疗,观察组在对照组基础上采用小儿肺咳颗粒治疗,比较两组临床疗效、住院时间、症状指标恢复时间(咳嗽痰响消失时间、啰音消失时间)及治疗前后血清炎症因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)]水平。结果观察组治疗总有效率为93.33%,明显高于对照组的77.78%,差异有统计学意义(P<0.05)。观察组咳嗽痰响消失时间、住院时间及啰音消失时间均显著短于对照组,差异有统计学意义(P<0.05)。治疗前,两组血清CRP、IL-6水平比较差异无统计学意义;治疗后,两组血清CRP、IL-6水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论盐酸氨溴索联合小儿肺咳颗粒治疗小儿支原体肺炎效果显著,可降低患者炎症因子水平,缩短住院时间与临床症状消失时间,值得临床推广应用。

Objective To investigate the effect of Xiao'er Feike granules combined with ambroxol hydrochloride on the level of inflammatory factors in children with Mycoplasma pneumonia(MPP).Methods A total of 90 children with MPP admitted to the department of Pediatrics of the Second People's Hospital of Yichun from May 2020 to December 2021 were selected as the research subjects,and they were divided into control group and observation group according to different treatment plan,with 45 cases in each group.The control group was treated with ambroxol hydrochloride injection on the basis of symptomatic treatment,and the observation group was treated with Xiao'er Feike granules on the basis of the control group,and the clinical efficacy,hospitalization time,recovery time of symptom indicators(cough sputum disappearance time,rale disappearance time)and serum inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6)]levels before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.33%,which was significantly higher than 77.78%in the control group,and the difference was statistically significant(P<0.05).The hospitalization time,cough sputum disappearance time,rales disappearance time in the observation group were significantly shorter than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in serum levels of CRP,IL-6 between the two groups;after treatment,the levels of CRP and IL-6 in the two groups were lower than before treatment,and the observation group was lower than the control group,and the differences were statistically significant(P<0.05).Conclusion Ambroxol hydrochloride combined with Xiao'er Feike granules in the treatment of mycoplasma pneumonia in children has significant effect,can reduce the level of inflammatory factors,shorten the hospitalization time and the disappearance time of clinical symptoms,which is worthy of clinical promotion and application.