阿司匹林联合丁苯酞软胶囊治疗急性脑梗死的临床疗效及安全性

Efficacy and safety of aspirin combined with butylphthalide soft capsule in the treatment of acute cerebral infarction

目的探讨阿司匹林联合丁苯酞软胶囊治疗急性脑梗塞的临床疗效及安全性。方法采用分层抽样法选取2019年3月至2020年2月本院收治的80例急性脑梗塞患者作为研究对象,依据治疗方案的不同分为基础组和联合组,每组40例。基础组采用阿司匹林治疗,联合组采用阿司匹林联合丁苯酞软胶囊治疗,比较两组治疗前后神经功能、日常生活能力、炎症因子[同型半胱氨酸(Hcy)、肿瘤坏死因子-α(TNF-α)]水平及不良反应发生情况。结果治疗前,两组美国国立卫生研究院卒中量表(NIHSS)评分及Barthel指数(BI)评分比较差异无统计学意义;治疗后,两组NIHSS评分均低于治疗前,BI评分均高于治疗前,且联合组NIHSS评分低于基础组,BI评分高于基础组,差异有统计学意义(P<0.05)。治疗前,两组Hcy、TNF-α水平比较差异无统计学意义;治疗后,两组Hcy、TNF-α水平均低于治疗前,且联合组低于基础组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论阿司匹林联合丁苯酞软胶囊治疗急性脑梗塞能显著改善患者的神经功能及认知功能,有利于提高患者的日常生活能力,且用药安全性较高,值得临床推广应用。

Objective To investigate the efficacy and safety of aspirin combined with butylphthalide soft capsule in the treatment of acute cerebral infarction.Methods A total of 80 patients with acute cerebral infarction admitted to our hospital from March 2019 to February 2020 were selected as the research subjects by stratified sampling,and they were divided into basic group and combined group according to different treatment options,with 40 cases in each group.The basic group was treated with aspirin,and the combined group was treated with butyrophthalide soft capsule,and the neurological function,daily living ability,inflammatory factors(homocysteine[Hcy],tumor necrosis factor-α[TNF-α])before and after treatment and the occurrence of adverse reactions were compared between the two groups.Results Before treatment,there was no significant difference in the National Institute of Health stroke scale(NIHSS)and the Barthel index(BI)score between the two groups;after treatment,the NIHSS scores of the two groups were lower than those before treatment,the BI score of the two groups was higher than that before treatment,and the NIHSS scores of the combined group was lower than that of the basic group,and the BI score of the combined group was higher than that of the basic group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in Hcy and TNF-αlevels between the two groups;after treatment,Hcy and TNF-αlevels in two groups were lower than before treatment,and the combined group was lower than the basic group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Aspirin combined with butylphthalide soft capsule in the treatment of acute cerebral infarction can significantly improve the neurological function and cognitive function of patients,help to improve the ability of daily living of patients,and the drug safety is high,which is worthy of clinical promotion and application.