泮托拉唑联合奥曲肽对消化性溃疡出血患者出血时间及炎症因子水平的影响

Effects of pantoprazole combined with octreotide on bleeding time and inflammatory factor levels in patients with peptic ulcer bleeding

目的探讨泮托拉唑联合奥曲肽治疗消化性溃疡(PU)出血的临床效果和对炎症因子水平的影响。方法选取2018年7月至2020年7月于本院治疗的84例PU出血患者作为研究对象,按随机数字表法分为两组,各42例。两组均接受常规治疗,对照组在常规治疗基础上加用泮托拉唑治疗,观察组在对照组基础上加用奥曲肽治疗。比较两组临床疗效、出血时间和住院时间、治疗前后炎症因子白细胞介素(IL)-2、IL-6水平及不良反应发生情况。结果观察组治疗总有效率为95.24%,高于对照组的80.95%,差异有统计学意义(P<0.05)。观察组出血时间和住院时间均短于对照组,差异有统计学意义(P<0.05)。治疗前,两组IL-2、IL-6水平比较差异无统计学意义;治疗后,两组IL-2水平均高于治疗前,IL-6水平均低于治疗前,且观察组IL-2水平高于对照组,IL-6水平低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论泮托拉唑联合奥曲肽治疗PU出血,可增强止血效果,缩短出血控制时间,减轻胃肠黏膜严重反应,安全性高,值得临床推广应用。

Objective To investigate the clinical effect of pantoprazole combined with octreotide in the treatment of peptic ulcer(PU)bleeding and its influence on the level of inflammatory factors.Methods 84 patients with PU bleeding who were treated in our hospital from July 2018 to July 2020 were selected as the research subjects,and they were divided into two groups according to the random number table,with 42 cases in each group.Both groups received routine treatment,the control group was treated with pantoprazole on the basis of routine treatment,and the observation group was treated with octreotide on the basis of the control group.The clinical efficacy,bleeding time and hospitalization time,levels of inflammatory factors[interleukin(IL)-2,IL-6]before and after treatment and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.24%,which was higher than 80.95%of the control group(P<0.05).The bleeding time and hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of IL-2 and IL-6 between the two groups;after treatment,the level of IL-2 in the two groups was higher than that before treatment,level of IL-6 in the two groups was lower than that before treatment,and the level of IL-2 in the observation group was higher than that in the control group,level of IL-6 in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups.Conclusion Pantoprazole combined with octreotide can enhance the hemostatic effect of PU bleeding patients,shorten the bleeding control time,reduce the serious reaction of gastrointestinal mucosa,with high safety,and is worthy of clinical promotion and application.