非酒精性脂肪性肝病与慢性HBV感染的相关性研究

Relationship between nonalcoholic fatty liver disease and chronic HBV infection

目的研究分析非酒精性脂肪性肝病(NAFLD)与慢性HBV感染的相关性。方法选取2019年6月至2022年1月于本院门诊就诊的非酒精性脂肪性肝病感染者(NAFLD组,n=20)、慢性HBV感染者(HBV组,n=20)及NAFLD合并慢性HBV感染者(NAFLD合并HBV组,n=20),对其进行长期随访。比较3组生化学及病毒血清学的变化情况。结果60例患者纳入研究,其中男45例(75.0%),女15例(25.0%),不同性别的年龄与BMI比较差异有统计学意义(P<0.05),NAFLD合并HBV组、NAFLD组及HBV组ALT、TBil、HDL-C水平比较差异无统计学意义;NAFLD合并HBV组和NAFLD组AST水平均明显高于HBV组;NAFLD合并HBV组和NAFLD组ALB、GGT、空腹血糖、TC、TG、LDL-C水平均明显低于HBV组,差异有统计学意义(P<0.05)。NAFLD合并HBV患者、NAFLD患者及慢性HBV患者的病毒血清学(HBsAg、HBeAg、HbeAb、HbcAb、HBVDNA)比较差异均有统计学意义(P<0.05)。NAFLD合并HBV组、NAFLD组及HBV组HBsAg、HbcAb、HBVDNA比较差异均无统计学意义。NAFLD合并HBV组和NAFLD组HBeAg、HbeAb均高于HBV组,差异有统计学意义(P<0.05)。结论非酒精性脂肪性肝病与慢性HBV感染有一定的相关性,慢性HBV感染与非酒精性脂肪性肝病的低发病率相关。

Objective To study the correlation between nonalcoholic fatty liver disease(NAFLD)and chronic HBV infection.Methods The patients with nonalcoholic fatty liver disease infection(NAFLD group,n=20),chronic HBV infection(HBV group,n=20)and NAFLD with chronic HBV infection(NAFLD with HBV group,n=20)who were hospitalized in our hospital from June 2019 to January 2022 were selected for long-term followup.Observe the changes of biochemistry and virus serology,and analyze the differences and correlation between the three groups.Results 60 patients were included in the study,including 45 males(75.0%)and 15 females(25.0%).There was statistically significant difference between the age and BMI of different genders(P<0.05);AST levels in NAFLD combined with HBV group and NAFLD group were significantly higher than those in HBV group;The levels of ALB,GGT,fasting blood glucose,TC,TG and LDL-C in NAFLD combined with HBV group and NAFLD group were significantly lower than those in HBV group,the difference was statistically significant(P<0.05).The difference was statistically significant in virus serology(HBsAg,HBeAg,HbeAb,HbcAb,HBV DNA)of NAFLD patients with HBV,NAFLD patients and chronic HBV patients(P<0.05).There was no significant difference in HBsAg,HbcAb and HBV DNA between NAFLD combined with HBV group,NAFLD group and HBV group.HBeAg and HbeAb in NAFLD combined with HBV group and NAFLD group were significantly higher than those in HBV group(P<0.05).Conclusion Nonalcoholic fatty liver disease is associated with chronic HBV infection.Chronic HBV infection is associated with a low incidence rate of nonalcoholic fatty liver disease.