高强度聚焦超声消融术治疗不同大小子宫肌瘤的临床疗效及对患者妊娠结局的影响分析

The clinical efficacy of high intensity focused ultrasound ablation in the treatment of hysteromyoma of different sizes and its influence on pregnancy outcome

目的分析高强度聚焦超声消融术治疗不同大小子宫肌瘤的临床疗效与对患者妊娠结局的影响。方法回顾性分析2017年6月至2019年1月本院收治的112例子宫肌瘤患者的临床资料,运用宫腔镜子宫肌瘤切除术治疗的患者作为对照组,运用高强度聚焦超声消融术治疗的患者作为研究组,每组56例。比较两组治疗效率、性激素水平、妊娠结局。结果研究组治疗总有效率为96.43%,高于对照组的85.71%(P<0.05);术后1~2年,研究组自然受孕率均高于对照组,需行辅助生殖技术率低于对照组(P<0.05);研究组阴道分娩率、足月分娩率均高于对照组,剖腹产率、早产率均低于对照组(P<0.05);治疗6个月后,研究组LH、FSH的水平低于对照组(P<0.05)。结论高强度聚焦超声消融术治疗子宫肌瘤患者的疗效显著,可改善妊娠结局和性激素水平。

Objective To analyze the clinical efficacy of high-intensity focused ultrasound ablation in the treatment of uterine fibroids of different sizes and its influence on pregnancy outcome.Methods The clinical data of 112 patients with uterine fibroids admitted to our hospital from June 2017 to January 2019 were retrospectively analyzed,patients treated with hysteroscopic myomectomy were selected as the control group and those treated with high intensity focused ultrasound ablation as the study group,with 56 cases in each group.Treatment efficiency,sex hormone levels and pregnancy outcome were compared between the two groups.Results The total effective rate was 96.43% in the study group,which was higher than 85.71% in the control group(P<0.05).1-2 years after surgery,the rate of natural conception in the study group was higher than that in the control group,and the rate of assisted reproductive technology was lower than that in the control group(P<0.05).The vaginal delivery rate and full-term delivery rate in the study group were higher than those in the control group,and the cesarean section rate and premature delivery rate were lower than those in the control group(P<0.05).After 6 months of treatment,LH and FSH levels in the study group were lower than those in the control group(P<0.05).Conclusion High intensity focused ultrasound ablation is effective in the treatment of uterine fibroids and can improve pregnancy outcome and sex hormone levels.