老年首次非诱发性癫痫患者复发状况及其影响因素

Status and influencing factors of relapse in elderly patients with first non-induced epilepsy

目的探讨老年首次非诱发性癫痫患者复发状况及其影响因素。方法回顾性分析2019年1—12月于本院就诊的80例老年首次非诱发性癫痫患者的临床资料。统计随访1年内患者的复发情况,比较不同复发情况患者的临床资料,Logistic回归分析老年首次非诱发性癫痫患者复发情况的影响因素。结果随访1年内,80例老年首次非诱发性癫痫患者中,复发23例,复发率为28.75%。不同复发情况患者的性别、年龄发作形式及脑电图显示痫样放电情况比较差异无统计学意义;复发患者病灶累及皮质、睡眠中发作及有代谢疾病占比均高于未复发患者,差异有统计学意义(P<0.05)。Logistic回归分析结果显示,病灶累及皮质、睡眠中发作、有代谢性疾病均为老年首次非诱发性癫痫患者癫痫复发的影响因素(OR>1,P<0.05)。结论病灶累及皮质、睡眠中发作、有代谢性疾病均为老年首次非诱发性癫痫患者癫痫复发的影响因素,临床可针对性制定干预措施,以帮助患者康复。

Objective To status and investigate the relapse status and influencing factors in elderly patients with first non-induced epilepsy.Methods Clinical data of 80 elderly patients with first non-induced epilepsy admitted to our hospital from January 2019 to December 2019 were retrospectively analyzed.The recurrence of patients in 1 year was analyzed,the clinical data of patients with different recurrence conditions were compared.Logistic regression was used to analyze the factors influencing relapse in elderly patients with first non-induced epilepsy.Results Within 1 year of follow-up,among the 80 elderly patients with first non-induced epilepsy,23 cases had recurrence,and the recurrence rate was 28.75%.There was no significant difference in gender,age,epileptic seizure form and epileptic discharge in patients with different recurrence conditions;the proportion of focal cortical involvement,seizures during sleep and the metabolic disease in patients with recurrence were higher than those without recurrence,and the differences were statistically significant(P<0.05).Logistic regression analysis showed that lesions involving cortex,seizures during sleep and metabolic diseases were all factors affecting epilepsy recurrence in elderly patients with first non-induced epilepsy(OR>1,P<0.05).Conclusion Focal cortical involvement,seizures during sleep and metabolic diseases are the influencing factors of epilepsy recurrence in elderly patients with first non-induced epilepsy,clinical targeted intervention developed to help patients recover.