内镜下止血联合生长抑素治疗抗栓期间消化道出血的临床疗效

Clinical effect of endoscopic hemostasis combined with somatostatin in the treatment of gastrointestinal bleeding during antithrombotic period

目的探讨内镜下止血联合生长抑素治疗抗栓期间消化道出血的临床疗效。方法选取2020年1—12月本院收治的60例抗栓期间消化道中重度出血患者作为研究对象,按随机数字表法分为观察组和对照组,每组30例。对照组给予内镜下止血,观察组在对照组基础上联合生长抑素。比较两组临床疗效、临床指标(黑便消失时间、呕血消失时间、住院时间)、预后改善情况(24 h快速止血率、再出血发生率、不良心血管事件发生率)。结果观察组治疗总有效率为96.67%,明显高于对照组的73.33%,差异有统计学意义(P<0.05)。观察组黑便消失时间、呕血消失时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。观察组24 h快速止血率高于对照组,再出血率、不良心血管事件发生率均低于对照组,差异有统计学意义(P<0.05)。结论内镜下止血药物联合生长抑素治疗抗栓期间消化道出血疗效显著,可缩短症状消失时间及住院时间,降低再出血与不良心血管事件发生风险,有利于改善患者预后,值得临床推广应用。

Objective To investigate the clinical efficacy of endoscope hemostasis combined with somatostatin in the treatment of gastrointestinal bleeding during antithrombotic period.Methods 60 patients with moderate and severe gastrointestinal bleeding during antithrombotic period admitted to our hospital from January to December 2020 were selected as the research subjects,and they divided into observation group and control group according to random number table method,with 30 cases in each group.The control group received endoscopic hemostasis,and the observation group was combined with somatostatin on the basis of the control group.The clinical efficacy,clinical indicators(disappearance time of black stool and hematemesis,hospital stay)and improvement of prognosis(24 h rapid hemostasis rate,incidence of rebleeding,incidence of adverse cardiovascular events)were compared between the two groups.Results The total effective rate of observation group was 96.67%,which was significantly higher than 73.33%of control group,and the difference was statistically significant(P<0.05).The disappearance time of black stool,hematemesis and hospital stay in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The 24 h rapid hemostasis rate of the observation group was higher than that of the control group,and the incidtule rebleeding rate and the incidence of adverse cardiovascular events were lower than those of the control group,and the differences were statistically significant(P<0.05).Conclusion Endoscopic hemostatic drugs combined with somatostatin have significant efficacy in the treatment of gastrointestinal bleeding during antithrombotic period,which can shorten the time of symptom disappearance and hospital stay,reduce the risk of rebleeding and adverse cardiovascular events,improve the prognosis of patients,and is worthy of clinical promotion and application.